Document Detail

Regional brain [Met]-enkephalin in alcohol-preferring and non-alcohol-preferring inbred strains of mice.
MedLine Citation:
PMID:  3569490     Owner:  NLM     Status:  MEDLINE    
Scrutiny of the data from these studies reveals that the C58/J alcohol-preferring mice have significantly lower baseline methionine-enkephalin levels in both the corpus striatum and hypothalamus compared to C3H/CHRGL/2 non-alcohol-preferring mice. In other brain regions in these two strains, specifically, pituitary, amygdala, midbrain, and hippocampus, analysis of methionine-enkephalin levels did not show any significant differences. This suggests that the hypothalamus may indeed be a specific locus involved in the regulation of alcohol intake, via the molecular interaction between neuroamines, opioid peptides, as they are influenced by genetics and environment.
K Blum; A H Briggs; J E Wallace; C W Hall; M A Trachtenberg
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experientia     Volume:  43     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-06-01     Completed Date:  1987-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  408-10     Citation Subset:  IM    
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MeSH Terms
Alcohol Drinking / physiology*
Brain / metabolism*
Corpus Striatum / metabolism
Enkephalin, Methionine / metabolism*
Hypothalamus / metabolism
Mice, Inbred C3H
Mice, Inbred Strains
Reg. No./Substance:
58569-55-4/Enkephalin, Methionine

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