| Regional blood flow in rats after a single low-protein, high-carbohydrate test meal. | |
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MedLine Citation:
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PMID: 6742226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It was previously observed that a single low-protein, high-carbohydrate test meal results in increased in vitro thermic activity of brown adipose tissue. In the present study, we have examined whether such a meal increases the in vivo thermic activity, estimated from measurement of the rate of blood flow. With radioactively labeled microspheres, blood flows into brown fat and several other tissues were determined in meal-deprived (n = 11) and meal-fed (n = 11) rats. The microspheres were injected into the heart of anesthetized animals about 2-2.5 h after the test meal, one injection in the resting state and one during maximal norepinephrine stimulation. In the resting state, blood flow per gram tissue more than doubled in the brown fat (P less than 0.05) and was increased more than 50% in the heart (P less than 0.01) of the fed group. Blood flows into liver and retroperitoneal white fat were reduced by 40 (P less than 0.01) and 30%, respectively, in the fed group. During norepinephrine infusion, significant meal-associated increases in blood flow were evident only in brown fat (P less than 0.05) and the soleus muscle (P less than 0.05), whereas a significant decrease was observed in the liver (P less than 0.05). No statistically significant meal-associated changes in norepinephrine-stimulated blood flow were found in the other tissues examined (i.e., heart, gastrocnemius, and diaphragm muscles, kidneys, white fat, spleen, and adrenals). Our in vivo data thus support the view that brown fat plays a role in the thermic effect of a meal. |
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Authors:
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Z Glick; S J Wickler; J S Stern; B A Horwitz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 247 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1984 Jul |
Date Detail:
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Created Date: 1984-08-17 Completed Date: 1984-08-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R160-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue, Brown
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blood supply* Animals Body Temperature Regulation* Cerium Radioisotopes / diagnostic use Dietary Carbohydrates / administration & dosage* Dietary Proteins / administration & dosage* Female Hemodynamics / drug effects Microspheres Norepinephrine / pharmacology Rats Rats, Inbred Strains Regional Blood Flow Strontium Radioisotopes / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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AM-18899/AM/NIADDK NIH HHS; AM-27019/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cerium Radioisotopes; 0/Dietary Carbohydrates; 0/Dietary Proteins; 0/Strontium Radioisotopes; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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