Document Detail


Regional analysis of dynamic deformation characteristics of native aortic valve leaflets.
MedLine Citation:
PMID:  21458817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The mechanical environment of the aortic valve (AV) has a significant impact on valve cellular biology and disease progression, but the regional variation in stretch across the AV leaflet is not well understood. This study, therefore, sought to quantify the regional variation in dynamic deformation characteristics of AV leaflets in the native mechanical environment in order to link leaflet stretch variation to reported AV calcification patterns.
METHODS: Whole porcine AVs (n=6) were sutured into a physiological left heart simulator and subjected to pulsatile and physiologically normal hemodynamic conditions. A grid of ink dots was marked on the entire ventricular surface of the AV leaflet. Dual camera stereo photogrammetry was used to determine the stretch magnitudes across the entire ventricular surface over the entire diastolic duration.
RESULTS: Elevated stretch magnitudes were observed along the leaflet base and coaptation line consistent with previously reported calcification patterns suggesting the higher mechanical stretch experienced by the leaflets in these regions may contribute to increased disease propensity. Transient stretch overloads were observed during diastolic closing, predominantly along the leaflet base, indicating the presence of a dynamic fluid hammer effect resulting from retrograde blood flow impacting the leaflet. We speculate the function of the leaflet base to act in cooperation with the sinuses of Valsalva to dampen the fluid hammer effect and reduce stress levels imparted on the rest of the leaflet.
Authors:
Michael Weiler; Choon Hwai Yap; Kartik Balachandran; Muralidhar Padala; Ajit P Yoganathan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-04-01
Journal Detail:
Title:  Journal of biomechanics     Volume:  44     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-10-03     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1459-65     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aortic Valve / pathology,  physiology,  physiopathology*
Aortic Valve Stenosis / physiopathology
Equipment Design
Heart Valve Prosthesis
Models, Anatomic
Models, Biological
Models, Cardiovascular
Stress, Mechanical
Surface Properties
Swine
Grant Support
ID/Acronym/Agency:
HL-070262/HL/NHLBI NIH HHS; R01 HL070262/HL/NHLBI NIH HHS; R01 HL070262-08/HL/NHLBI NIH HHS
Comments/Corrections

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