Document Detail


Regional alveolar hypoxia does not affect air embolism-induced pulmonary edema.
MedLine Citation:
PMID:  2501279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effects of regional alveolar hypoxia on permeability pulmonary edema resulting from venous air embolization. Anesthetized dogs had the left upper lobe removed and a double-lumen tube placed so that right lung and left lower lobe (LLL) could be ventilated independently. Air was infused into the femoral vein for 1 h during bilateral ventilation at an inspiratory O2 fraction (FIO2) of 1.0. After cessation of air infusion the LLL was then ventilated with a hypoxic gas mixture (FIO2 = 0.05) in six animals and an FIO2 of 1.0 in six other animals. Lung hydroxyproline content was measured as an index of lung dry weight. LLL bloodless lobar wet weight-to-hydroxyproline ratio was 0.33 +/- 0.06 mg/micrograms in the animals exposed to LLL hypoxia and 0.37 +/- 0.03 mg/micrograms (NS) in the animals that had a LLL FIO2 of 1. Both values were significantly higher than our laboratory normal values of 0.19 +/- 0.01 mg/micrograms. We subsequently found in four more dogs exposed to global alveolar hypoxia before and after air embolism that the air injury itself significantly depressed the hypoxic vasoconstrictor response. We conclude that regional alveolar hypoxia has no effect on pulmonary edema formation due to air embolism. The most likely reason for these findings is that the air embolism injury itself interfered with hypoxic pulmonary vasoconstriction.
Authors:
F W Cheney; B L Eisenstein; P T Overand; M J Bishop
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  66     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2369-73     Citation Subset:  IM; S    
Affiliation:
Department of Anesthesiology, University of Washington, School of Medicine, Seattle 98195.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / complications,  physiopathology*
Blood Pressure
Carbon Dioxide / blood
Dogs
Embolism, Air / complications,  physiopathology*
Female
Hemodynamics*
Hydroxyproline / analysis
Lung / physiopathology*
Male
Oxygen / blood
Partial Pressure
Pulmonary Alveoli / physiopathology*
Pulmonary Circulation*
Pulmonary Edema / etiology,  physiopathology*
Reference Values
Grant Support
ID/Acronym/Agency:
HL-24163/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 51-35-4/Hydroxyproline; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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