Document Detail

Regional adaptations in PSD-95, NGFI-A and secretogranin gene transcripts related to vulnerability to behavioral sensitization to amphetamine in the Roman rat strains.
MedLine Citation:
PMID:  18093743     Owner:  NLM     Status:  MEDLINE    
Genetically selected for high or low two-way active avoidance, Roman high-avoidance (RHA) and Roman low-avoidance (RLA) rats differ in their central dopaminergic activity, sensation/novelty- and substance-seeking profiles. These animals are, therefore, well suited to identify anatomical and neurochemical concomitants of behavioral sensitization, a phenomenon linked to addictive liability. We submitted inbred RHA (RHA-I), inbred RLA (RLA-I) and Sprague-Dawley-OFA (SD-OFA) rats to a sensitization regimen with amphetamine and studied the behavioral response to an amphetamine challenge after a 2-week withdrawal period. The expression patterns of nerve growth factor inducible clone A (NGFI-A), secretogranin, post-synaptic density protein of 95 Kd (PSD-95), prodynorphin and proenkephalin mRNA were also analyzed using in situ hybridization, after the challenge with amphetamine. RHA-I rats showed stronger sensitization than SD-OFA rats. RLA-I rats did not show sensitization but were hyper-reactive to amphetamine. Expression of behavioral sensitization in RHA-I rats activated secretogranin and PSD-95 mRNA in the nucleus accumbens core. On the other hand, high induction of NGFI-A mRNA in the central amygdala was observed in RLA-I rats when they experienced amphetamine for the first time in the challenge. Our results reveal that 1) the acute locomotor response to amphetamine does not predict vulnerability to behavioral sensitization and 2) differences in vulnerability to sensitization may involve distinctive cellular adaptations at particular brain locations which may be related to addictive vulnerability.
M Guitart-Masip; B Johansson; T Cañete; A Fernández-Teruel; A Tobeña; L Terenius; L Giménez-Llort
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-11
Journal Detail:
Title:  Neuroscience     Volume:  151     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-208     Citation Subset:  IM    
Department of Psychiatry and Forensic Medicine, Institute of Neuroscience, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain.
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MeSH Terms
Amphetamine / pharmacology*
Behavior, Animal / drug effects*
Central Nervous System Stimulants / pharmacology*
Chromogranins / biosynthesis,  genetics*
Dynorphins / biosynthesis,  genetics
Early Growth Response Protein 1 / biosynthesis,  genetics*
Enkephalins / biosynthesis,  genetics
In Situ Hybridization
Intracellular Signaling Peptides and Proteins / genetics*
Membrane Proteins / biosynthesis,  genetics*
Motor Activity / drug effects
Nucleus Accumbens / drug effects,  metabolism
Oligodeoxyribonucleotides / diagnostic use
Protein Precursors / biosynthesis,  genetics
Rats, Inbred Strains
Rats, Sprague-Dawley
Species Specificity
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Chromogranins; 0/Dlgh4 protein, rat; 0/Early Growth Response Protein 1; 0/Egr1 protein, rat; 0/Enkephalins; 0/Intracellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Oligodeoxyribonucleotides; 0/Protein Precursors; 0/proenkephalin; 300-62-9/Amphetamine; 74913-18-1/Dynorphins

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