| Regional Cooling Facilitates Termination of Spiral-Wave Reentry through Unpinning of Rotors in Rabbit Hearts. | |
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MedLine Citation:
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PMID: 21839044 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Moderate global cooling of myocardial tissue was shown to destabilize 2-dimensional (2-D) reentry and facilitate its termination. OBJECTIVE: To test the hypothesis that regional cooling destabilizes rotors and facilitates termination of spontaneous and DC-shock-induced subepicardial reentry in isolated, endocardially ablated rabbit hearts. METHODS: Fluorescent action potential signals were recorded from 2-D subepicardial ventricular myocardium of Langendorff-perfused rabbit hearts. Regional cooling (by 5.9±1.3°C) was applied to the left ventricular anterior wall using a transparent cooling device (10 mm in diameter). RESULTS: Regional cooling during constant stimulation (2.5 Hz) prolonged the action potential duration (by 36±9%) and slightly reduced conduction velocity (by 4±4%) in the cooled region. Ventricular tachycardias (VTs) induced during regional cooling terminated earlier than those without cooling (control): VTs lasting >30 s were reduced from 17/39 to 1/61. When regional cooling was applied during sustained-VTs (>120 s), 16/33 (48%) sustained-VTs self-terminated in 12.5±5.1 s. VT termination was the result of rotor destabilization, which was characterized by unpinning, drift toward the periphery of the cooled region and subsequent collision with boundaries. The DC-shock intensity required for cardioversion of the sustained-VTs decreased significantly by regional cooling (22.8±4.1 V, n=16 vs. 40.5±17.6 V, n=21). The major mode of reentry termination by DC-shocks was phase resetting in the absence of cooling, whereas unpinning in the presence of cooling. CONCLUSION: Regional cooling facilitates termination of 2-D reentry through unpinning of rotors. |
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Authors:
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Masatoshi Yamazaki; Haruo Honjo; Takashi Ashihara; Masahide Harada; Ichiro Sakuma; Kazuo Nakazawa; Natalia Trayanova; Minoru Horie; Jérôme Kalifa; José Jalife; Kaichiro Kamiya; Itsuo Kodama |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-9 |
Journal Detail:
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Title: Heart rhythm : the official journal of the Heart Rhythm Society Volume: - ISSN: 1556-3871 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101200317 Medline TA: Heart Rhythm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan; Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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