| Region and labour-dependent synthesis of prostaglandin E2 by human fetal membranes. | |
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MedLine Citation:
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PMID: 10195739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine the effect of region and labour upon prostaglandin synthesis in human fetal membranes, intact membranes from three regions, the cervical region, the periplacental region and a region midway between the two, were collected following spontaneous labour and delivery or at elective caesarean section prior to labour. Discs of 2-cm diameter were cut from each of three regions and incubated for 1, 2, 4, 6, 12 or 24 h after which prostaglandin E2 concentration in the supernatant was measured. We found that there was an overall decrease in prostaglandin synthesis in tissues collected after labour, but that this effect could be reversed if exogenous arachidonic acid substrate was supplied. We found no differences in prostaglandin synthesis between tissues collected from each of the three regions. We conclude that prostaglandin synthesis from the fetal membranes during labour leads to depletion of arachidonic acid substrate and that regional changes in prostaglandin dehydrogenase activity do not appear to have a significant effect upon overall prostaglandin synthesis. |
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Authors:
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R J Sawdy; W J Dennes; V Allport; D M Slater; M G Elder; M H Sullivan; P R Bennett |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Placenta Volume: 20 ISSN: 0143-4004 ISO Abbreviation: Placenta Publication Date: 1999 Mar-Apr |
Date Detail:
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Created Date: 1999-05-27 Completed Date: 1999-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 181-4 Citation Subset: IM |
Affiliation:
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Imperial College School of Medicine, Institute of Obstetrics and Gynaecology, Queen Charlottes and Chelsea Hospital, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arachidonic Acid
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pharmacology Cervix Uteri Cesarean Section Culture Media Culture Techniques Dinoprostone / biosynthesis* Extraembryonic Membranes / metabolism* Female Humans Labor, Obstetric / physiology* Placenta Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 363-24-6/Dinoprostone; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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