Document Detail

Region and labour-dependent synthesis of prostaglandin E2 by human fetal membranes.
MedLine Citation:
PMID:  10195739     Owner:  NLM     Status:  MEDLINE    
To examine the effect of region and labour upon prostaglandin synthesis in human fetal membranes, intact membranes from three regions, the cervical region, the periplacental region and a region midway between the two, were collected following spontaneous labour and delivery or at elective caesarean section prior to labour. Discs of 2-cm diameter were cut from each of three regions and incubated for 1, 2, 4, 6, 12 or 24 h after which prostaglandin E2 concentration in the supernatant was measured. We found that there was an overall decrease in prostaglandin synthesis in tissues collected after labour, but that this effect could be reversed if exogenous arachidonic acid substrate was supplied. We found no differences in prostaglandin synthesis between tissues collected from each of the three regions. We conclude that prostaglandin synthesis from the fetal membranes during labour leads to depletion of arachidonic acid substrate and that regional changes in prostaglandin dehydrogenase activity do not appear to have a significant effect upon overall prostaglandin synthesis.
R J Sawdy; W J Dennes; V Allport; D M Slater; M G Elder; M H Sullivan; P R Bennett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Placenta     Volume:  20     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    1999 Mar-Apr
Date Detail:
Created Date:  1999-05-27     Completed Date:  1999-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  181-4     Citation Subset:  IM    
Imperial College School of Medicine, Institute of Obstetrics and Gynaecology, Queen Charlottes and Chelsea Hospital, London, UK.
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MeSH Terms
Arachidonic Acid / pharmacology
Cervix Uteri
Cesarean Section
Culture Media
Culture Techniques
Dinoprostone / biosynthesis*
Extraembryonic Membranes / metabolism*
Labor, Obstetric / physiology*
Reg. No./Substance:
0/Culture Media; 363-24-6/Dinoprostone; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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