| Region [corrected] of slowed conduction acts as core for spiral wave reentry in cardiac cell monolayers. | |
| | |
MedLine Citation:
|
PMID: 17965287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Pathophysiological heterogeneity in cardiac tissue is related to the occurrence of arrhythmias. Of importance are regions of slowed conduction, which have been implicated in the formation of conduction block and reentry. Experimentally, it has been a challenge to produce local heterogeneity in a manner that is both reversible and well controlled. Consequently, we developed a dual-zone superfusion chamber that can dynamically create a small (5 mm) central island of heterogeneity in cultured cardiac cell monolayers. Three different conditions were studied to explore the effect of regionally slowed conduction on wave propagation and reentry: depolarization by elevated extracellular potassium, sodium channel inhibition with lidocaine, and cell-cell decoupling with palmitoleic acid. Using optical mapping of transmembrane voltage, we found that the central region of slowed conduction always served as the core region around which a spiral wave formed and then revolved following a period of rapid pacing. Because of the localized slowing in the core region, we observed experimentally for the first time an S shape of the spiral wave front near its tip. These results indicate that a small region of slowed conduction can play a crucial role in the formation, anchoring, and modulation of reentrant spiral waves. |
| | |
Authors:
|
Joyce W Lin; Libet Garber; Yue Rosa Qi; Marvin G Chang; Joshua Cysyk; Leslie Tung |
Related Documents
:
|
21231477 - Optical möbius symmetry in metamaterials. 18002107 - Dynamic qt/rr coupling in patients with pacemakers. 21720687 - Finite size scaling in the local abundances of geographic populations. 21164627 - Numerical study on terahertz random lasing in disordered ruby with three-level atomic s... 23363087 - In situ estimation of applied biaxial loads with lamb waves. 23112347 - Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultra... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-10-26 |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: 294 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2008 Jan |
Date Detail:
|
Created Date: 2008-01-14 Completed Date: 2008-02-28 Revised Date: 2008-04-30 |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: H58-65 Citation Subset: IM |
Affiliation:
|
Department of Biomedical Engineering, The Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Action Potentials*
/
drug effects Animals Animals, Newborn Anti-Arrhythmia Agents / pharmacology Arrhythmias, Cardiac / metabolism*, physiopathology Cardiac Pacing, Artificial Cell Culture Techniques / instrumentation* Cells, Cultured Equipment Design Fatty Acids, Monounsaturated / pharmacology Heart Ventricles / cytology, metabolism Lidocaine / pharmacology Myocytes, Cardiac / drug effects, metabolism* Potassium / metabolism Rats Rats, Sprague-Dawley Signal Processing, Computer-Assisted Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HL 66239/HL/NHLBI NIH HHS; R21 EB 006171/EB/NIBIB NIH HHS; R21 RR 017073/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Arrhythmia Agents; 0/Fatty Acids, Monounsaturated; 137-58-6/Lidocaine; 2091-29-4/palmitoleic acid; 7440-09-7/Potassium |
| Comments/Corrections | |
Erratum In:
|
Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1501 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cerebral blood flow is increased during controlled ovarian stimulation.
Next Document: Redox-dependent coronary metabolic dilation.