| Region-wise distribution of high-risk human papillomavirus types in squamous cell carcinomas of the cervix in India. | |
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MedLine Citation:
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PMID: 20683415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HYPOTHESIS: Assessment of the prevalence and type distribution of human papillomavirus (HPV) in squamous cell carcinomas (SCC) of the cervix across India was undertaken to estimate the impact of available prophylactic HPV-L1 vaccines in the country and to find out additional types that might be needed to be incorporated in second-generation vaccines. METHODS: High-risk (HR) HPVs were genotyped from 667 histopathologically confirmed cases of SCC from 6 different centers representing 4 regions across India: Advanced Centre for Treatment, Research and Education in Cancer, Mumbai; All India Institute of Medical Sciences, New Delhi; Cancer Foundation of India, Kolkata; Christian Medical College, Vellore; Kidwai Memorial Institute of Oncology, Bangalore; and Regional Cancer Center, Thiruvananthapuram. Human papillomaviruses in tumor biopsies were analyzed by Xcytonscreen HPV based on PGMY09/11 multiplex polymerase chain reaction and reverse dot blot assay. RESULTS: Overall viral prevalence across India was not different; 92.1% of 667 cases harbored HPV; 8% were negative. Infection with single HR type was seen in 86.8%: predominant types being HPV-16 followed by HPV-18, -45, -73, -31, -56, -52, -58, -59, -33, -68, -51, -35, -26, and -39. Human papillomavirus types 16/18-positive fraction formed 79.6%; other types comprised 12.4%. CONCLUSIONS: Prophylactic HPV-16/18-L1 vaccines would provide greater than 75% protection against SCC in India. Ranking and frequencies of non-16/18 types were different from earlier reports. Hence, considering the possibility of promotion of persistence of nonvaccine types in the vaccinees due to original antigenic sin and the lack of organized screening programs in India, a broad-based vaccine approach would be appropriate. |
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Authors:
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Radhakrishna M Pillai; Janaki M Babu; Vinoda T Jissa; S Lakshmi; Shubhada V Chiplunkar; M Patkar; H Tongaonkar; Krishnamurthy B Reddy; Kumar N Chakka; M Siddiqui; Soma Roychoudury; Priya Abraham; Abraham Peedicayil; M Gnanamony; J Subashini; T S Ram; Bindu Dey; Neeta Singh; Archana Singh; S K Jain; R S Jayshree |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Volume: 20 ISSN: 1525-1438 ISO Abbreviation: Int. J. Gynecol. Cancer Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-04 Completed Date: 2010-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111626 Medline TA: Int J Gynecol Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1046-51 Citation Subset: IM |
Affiliation:
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Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Distribution Aged Aged, 80 and over Biopsy, Needle Carcinoma, Squamous Cell / epidemiology*, pathology, virology* Cohort Studies DNA, Viral / analysis Female Human papillomavirus 16 / genetics, isolation & purification Human papillomavirus 18 / genetics, isolation & purification Humans Immunohistochemistry India / epidemiology Middle Aged Papillomaviridae / genetics, isolation & purification Papillomavirus Infections / epidemiology*, pathology, prevention & control Papillomavirus Vaccines / administration & dosage Polymerase Chain Reaction Precancerous Conditions / epidemiology, pathology Prevalence Risk Assessment Uterine Cervical Neoplasms / epidemiology*, pathology, virology* Vaginal Smears |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral; 0/Papillomavirus Vaccines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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