| Regio- and stereo-selectivity in the induction of peroxisome proliferation by substituted hexanoic acids. | |
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MedLine Citation:
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PMID: 8518749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Quantitative structure-activity relationship is an effective tool in order to predict drug potency. A similar approach is actually developed for peroxisome proliferation induced by substituted carboxylic acids issued from plasticizer metabolism in rats. The study is focused on acids found in rat urine after adipic diester dosings. Size, location of the substituted group and length of the chain have been studied. 3-D structure has also been taken in account for 2-ethyl hexanoic acids. The results obtained so far demonstrate that peroxisome proliferation potencies of the considered acids are modified according structure changes. At this time location of the group along the chain appears to be a predominant factor. |
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Authors:
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A C Macherey; I Leguy; S Gregoire; G Tainturier; J C Lhuguenot |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biology of the cell / under the auspices of the European Cell Biology Organization Volume: 77 ISSN: 0248-4900 ISO Abbreviation: Biol. Cell Publication Date: 1993 |
Date Detail:
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Created Date: 1993-07-29 Completed Date: 1993-07-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8108529 Medline TA: Biol Cell Country: FRANCE |
Other Details:
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Languages: eng Pagination: 9-11 Citation Subset: IM |
Affiliation:
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ENS BANA, Université de Bourgogne, Dijon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Hexanoic Acids / pharmacology* Liver / drug effects*, ultrastructure Male Microbodies / drug effects* Molecular Conformation Rats Rats, Wistar Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Hexanoic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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