| Regio- and enantioselective oxidation of thiaoleic acids by an algal delta 12-desaturase. | |
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MedLine Citation:
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PMID: 10570826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a non aerated incubation medium, the oxidation of the tested thiaoleic acids by C. vulgaris was regioselective. Moreover the non oxidised 14-thiaoleic acid had no influence on the endogenous fatty acid pattern whereas the 13-thiaoleic acid, readily oxidised by the microalgae, caused a significant 18:1 accumulation in phospholipids. Examination of the 13-thiaoleic acid metabolism revealed that up to 15% of the substrate was specifically oxidised in the phospholipids before being transferred into the neutral lipids class of C. vulgaris. Confirmation of the monooxygenase-like delta 12-desaturase intervention in this biotransformation was obtained by the stereochemical analysis of the optically active sulfoxide isolated from the endoplasmic phospholipids. |
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Authors:
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L Fauconnot; C Nugier-Chauvin; N Noiret; S Poulain; H Patin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Phytochemistry Volume: 52 ISSN: 0031-9422 ISO Abbreviation: Phytochemistry Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-12-20 Completed Date: 1999-12-20 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0151434 Medline TA: Phytochemistry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 567-73 Citation Subset: IM |
Affiliation:
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Laboratoire de Chimie Organique et des Substances Naturelles, ESA CNRS 6052, Ecole Nationale Supérieure de Chimie de Rennes, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acyl Coenzyme A
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metabolism Biotransformation Cells, Cultured Chlorella / enzymology*, metabolism Lipid Metabolism Oleic Acids / metabolism* Oxidation-Reduction Phospholipids / metabolism Stearoyl-CoA Desaturase / metabolism* Stereoisomerism Substrate Specificity Sulfoxides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Acyl Coenzyme A; 0/Oleic Acids; 0/Phospholipids; 0/Sulfoxides; EC 1.14.19.1/Stearoyl-CoA Desaturase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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