| Regio-distribution of stearic acid is not conserved in chylomicrons after ingestion of randomised, stearic acid-rich fat in a single meal. | |
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MedLine Citation:
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PMID: 19195862 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stearic acid from conventional food is well absorbed, but the fate of synthetic randomized stearic acid in fat absorption and subsequent metabolism is unclear. In this study, we examined the postprandial triglyceridemia following an ingestion of randomized stearic acid-rich fat. Following a 12-h fast, nine healthy young males ate a hamburger meal with 16.7 g of stearic acid (30% in triacylglycerol (TAG) sn-2 position, fully randomized). Postprandial blood samples were collected for 450 min, and the stearic acid content in chylomicron (CM, Svedberg flotation rate >400) TAG and the proportion of stearic acid in the sn-2 position were measured by tandem mass spectrometry at peak (180 min) and late (360 min) triglyceridemia. Of all stearic acid in CM TAG, 23% and 22% were in the sn-2 position at peak and late triglyceridemia (P<.004 and P<.001, respectively). This suggests a 68% and 62% conservation of sn-2 stearic acid, respectively. Peak postprandial TAG concentration and incremental area under the TAG curve showed a higher correlation with the fasting CM TAG (r=0.88, P<.01 and r=0.72, P<.05, respectively) than with total fasting plasma TAG (r=0.73, P<.05 and r=0.24, nonsignificant, respectively). In an earlier study, we showed that the absorption efficiency of the stearic acid of the meal was normal, with only marginal amounts of mainly sn-1,3 stearic acid found in the feces. In conclusion, we showed that sn-2 stearic acid is underrepresented in the postprandial CM TAG following an ingestion of fully randomized fat. |
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Authors:
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Saska S Tuomasjukka; Matti H Viitanen; Heikki P Kallio |
Publication Detail:
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Type: Journal Article Date: 2009-02-05 |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 20 ISSN: 1873-4847 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-13 Completed Date: 2010-01-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 909-15 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Food Chemistry, University of Turku, 20014 Turku, Finland. saska.tuomasjukka@utu.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chylomicrons
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metabolism* Dietary Fats / metabolism* Food Humans Isomerism Male Postprandial Period Stearic Acids / metabolism* Triglycerides / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Chylomicrons; 0/Dietary Fats; 0/Stearic Acids; 0/Triglycerides; 57-11-4/stearic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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