Document Detail


Regenerative therapies in electrophysiology and pacing.
MedLine Citation:
PMID:  18363088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prevention and treatment of cardiac arrhythmias conferring major morbidity and mortality is far from optimal, and relies heavily on devices and drugs for the partial successes that have been seen. The greatest success has been in the use of electronic pacemakers to drive the hearts of patients having high degree heart block. Recent years have seen the beginnings of attempts to use novel approaches available through gene and cell therapies to treat both brady- and tachyarrhythmias. By far the most successful approaches to date have been seen in the development of biological pacemakers. However, the far more difficult problems posed by atrial fibrillation and ventricular tachycardia are now being addressed. In the following pages we review the approaches now in progress as well as the specific methodologic demands that must be met if these therapies are to be successful.
Authors:
Michael R Rosen; Peter R Brink; Ira S Cohen; Peter Danilo; Richard B Robinson; Amy B Rosen; Matthias J Szabolcs
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-03-25
Journal Detail:
Title:  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing     Volume:  22     ISSN:  1383-875X     ISO Abbreviation:  J Interv Card Electrophysiol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-14     Completed Date:  2008-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708966     Medline TA:  J Interv Card Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-98     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. mrr1@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Arrhythmias, Cardiac / therapy*
Cardiac Pacing, Artificial / methods
Electrophysiologic Techniques, Cardiac / methods
Gene Therapy / methods*
Humans
Tissue Therapy / methods*
Grant Support
ID/Acronym/Agency:
HL-28958/HL/NHLBI NIH HHS; HL-67101/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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