| Regenerative stimulus increases hepatocyte tight junctional permeability. | |
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MedLine Citation:
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PMID: 1398486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experience with young animals, animals administered certain hepatotoxins and animals with two-thirds hepatectomy suggests that tight junctional permeability is increased in states characterized by architectural remodeling in the liver. In this work we correlate changes in tight junctional morphometry induced by two-thirds hepatectomy with changes in biliary permeability assessed by sucrose and horseradish peroxidase permeation and by alterations in biliary outputs of anionic and cationic cholephilic probes. By freeze-fracture examination tight junctional strand counts, density and orientation parallel to canaliculi were all reduced 24 hr after two-thirds hepatectomy. Occasionally, strands were perpendicular to the canaliculi, creating an unobstructed communication between bile and intercellular spaces. These morphological changes correlated with increased sucrose and paracellular horseradish peroxidase access into bile, with reduced biliary outputs of low molecular weight and especially with cationic cholephilic probes. The data support an increased but still charge-selective permeability of the biliary tree, which was induced by two-thirds hepatectomy 24 hr before. Presumably, fixed intercellular connections (tight junctions and gap junctions) must be loosened or lysed to allow the architectural reorganization required by the hepatocellular regenerative process. |
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Authors:
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S Poucell; W G Hardison; K Miyai |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 16 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-11-19 Completed Date: 1992-11-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1061-8 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of California, San Diego School of Medicine 92093. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / metabolism Hepatectomy / methods Horseradish Peroxidase / pharmacokinetics Intercellular Junctions / metabolism* Liver / metabolism*, ultrastructure Liver Regeneration* Male Permeability Rats Rats, Sprague-Dawley Taurocholic Acid / analogs & derivatives, pharmacology Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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AM-16100/AM/NIADDK NIH HHS; DK-28446/DK/NIDDK NIH HHS; RR-08135/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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517-37-3/taurodehydrocholate; 81-24-3/Taurocholic Acid; EC 1.11.1.-/Horseradish Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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