| Regenerative responses in larval axolotl limbs with skin grafts over the amputation surface. | |
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MedLine Citation:
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PMID: 381569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Complete flaps of whole skin over the amputation surface of larval axolotl limbs did not prevent dedifferentiation, DNA synthesis, and mitosis. However, even by two weeks, insufficient cell division had occurred for blastema formation. In about 50% of the cases, small areas of wound epidermis formed over the amputated tip of the radius or ulna. At two weeks after amputation, mitotic figures and dedifferentiated cells which incorporated H3-thymidine were predominantly located in the vicinity of the small area of wound epidermis. Although delayed in relation to controls, these limbs regenerated. The results are consistent with the view that the wound epidermis is necessary to maintain dedifferentiated cells in the cell cycle. |
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Authors:
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R A Tassava; D J Garling |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of experimental zoology Volume: 208 ISSN: 0022-104X ISO Abbreviation: J. Exp. Zool. Publication Date: 1979 Apr |
Date Detail:
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Created Date: 1979-10-24 Completed Date: 1979-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375365 Medline TA: J Exp Zool Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 97-110 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ambystoma
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physiology* Animals Cell Differentiation Cell Division Epidermis / pathology Extremities / physiology* Larva Mitosis Regeneration* Skin Transplantation Transplantation, Homologous Wounds and Injuries / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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