| Regenerative medicine in urology. | |
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MedLine Citation:
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PMID: 21895928 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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What's known on the subject? and What does the study add? Urology was one of the first specialties to report the introduction of regenerative medicine into clinical practice and has been at the forefront of scientific innovation. Despite the scale of investment and research effort, the promise of regenerative medicine remains largely unfulfilled. We review recent developments underpinning the emerging science of regenerative medicine and evaluate critically both the potential for novel regenerative therapies to transform urological practice and the outstanding challenges that remain to be addressed. The term 'regenerative medicine' encompasses strategies for restoring or renewing tissue or organ function by: (i) in vivo tissue repair by in-growth of host cells into an acellular natural or synthetic biomaterial, (ii) implantation of tissue 'engineered'in vitro by seeding cultured cells into a biomaterial scaffold, and (iii) therapeutic cloning and stem cell-based tissue regeneration. In this article, we review recent developments underpinning the emerging science of regenerative medicine and critically assess where successful implementation of novel regenerative medicine approaches into urology practice might genuinely transform the quality of life of affected individuals. We advocate the need for an evidence-based approach supported by strong science and clinical objectivity. |
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Authors:
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Felix Wezel; Jennifer Southgate; David F M Thomas |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-6 |
Journal Detail:
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Title: BJU international Volume: - ISSN: 1464-410X ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886721 Medline TA: BJU Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 THE AUTHORS. BJU INTERNATIONAL © 2011 BJU INTERNATIONAL. |
Affiliation:
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Jack Birch Unit for Molecular Carcinogenesis, Department of Biology, University of York, York Paediatric Urology, St James's University Hospital, Leeds, UK Department of Urology, University Medical Centre Mannheim, Germany. |
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