Document Detail


Regenerative medicine in the treatment of peripheral arterial disease.
MedLine Citation:
PMID:  19711369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The last decade has witnessed a dramatic increase in the mechanistic understanding of angiogenesis and arteriogenesis, the two processes by which the body responds to obstruction of large conduit arteries. This knowledge has been translated into novel therapeutic approaches to the treatment of peripheral arterial disease, a condition characterized by progressive narrowing of lower extremity arteries and heretofore solely amenable to surgical revascularization. Clinical trials of molecular, genetic, and cell-based treatments for peripheral artery obstruction have generally provided encouraging results.
Authors:
Erica B Sneider; Philip T Nowicki; Louis M Messina
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Journal of cellular biochemistry     Volume:  108     ISSN:  1097-4644     ISO Abbreviation:  J. Cell. Biochem.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-26     Completed Date:  2010-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205768     Medline TA:  J Cell Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  753-61     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
Affiliation:
Department of Surgery, Division of Vascular Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia
Arteries / pathology
Clinical Trials as Topic
Disease Progression
Female
Gene Therapy / methods
Gene Transfer Techniques
Humans
Neovascularization, Pathologic
Peripheral Vascular Diseases / genetics,  therapy*
Phenotype
Regenerative Medicine / methods*
Stress, Mechanical
Vascular Endothelial Growth Factor A / metabolism
Grant Support
ID/Acronym/Agency:
HL75353/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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