| Regenerative effect of basic fibroblast growth factor on periodontal healing in two-wall intrabony defects in dogs. | |
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MedLine Citation:
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PMID: 20447261 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The aim of the present study was to evaluate the effect of a basic fibroblast growth factor (bFGF) candidate treatment on periodontal healing in two-wall intrabony defects in dogs. MATERIALS AND METHODS: Two-wall intrabony defects (5 x 5 x 5 mm) were created surgically on the distal and mesial sides of bilateral mandibular second and fourth premolars in four Beagle dogs. bFGF, enamel matrix derivative (EMD) and platelet-derived growth factor with beta-tricalcium phosphate (PDGF/beta-TCP) treatments, and sham-surgery (OFD) were rotated among the four defects in each animal, EMD and PDGF/beta-TCP serving as benchmark controls. The animals were euthanized for radiographic and histologic evaluation at 8 weeks. RESULTS: Bone formation was significantly greater in the bFGF group (4.11 +/- 0.77 mm) than in the EMD (3.32 +/- 0.71 mm; p<0.05) and OFD (3.09 +/- 0.52 mm; p<0.01) groups. The EMD (4.59 +/- 1.19 mm) and PDGF/beta-TCP (4.66 +/- 0.7 mm) groups exhibited significantly greater cementum regeneration with periodontal ligament-like tissue than the OFD group (2.96 +/- 0.69 mm; p<0.01). No significant differences were observed between the bFGF and the PDGF/beta-TCP groups in any of the histometric parameters. CONCLUSIONS: The candidate bFGF treatment supported periodontal regeneration comparable with that of established benchmarks: EMD and PDGF/beta-TCP. |
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Authors:
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Yoshinori Shirakata; Katsuyoshi Taniyama; Takehiko Yoshimoto; Motoharu Miyamoto; Naoshi Takeuchi; Takashi Matsuyama; Kazuyuki Noguchi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical periodontology Volume: 37 ISSN: 1600-051X ISO Abbreviation: J. Clin. Periodontol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425123 Medline TA: J Clin Periodontol Country: Denmark |
Other Details:
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Languages: eng Pagination: 374-81 Citation Subset: D; IM |
Affiliation:
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Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. syoshi@dent.kagoshima-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alveolar Bone Loss
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drug therapy* Animals Bone Regeneration / drug effects*, physiology Bone Substitutes / therapeutic use Dental Enamel Proteins / therapeutic use Disease Models, Animal Dogs Fibroblast Growth Factor 2 / physiology*, therapeutic use Male Mandible / drug effects*, surgery Periodontium / drug effects*, physiology Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Bone Substitutes; 0/Dental Enamel Proteins; 0/enamel matrix proteins; 103107-01-3/Fibroblast Growth Factor 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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