Document Detail

Regenerative effect of basic fibroblast growth factor on periodontal healing in two-wall intrabony defects in dogs.
MedLine Citation:
PMID:  20447261     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of the present study was to evaluate the effect of a basic fibroblast growth factor (bFGF) candidate treatment on periodontal healing in two-wall intrabony defects in dogs. MATERIALS AND METHODS: Two-wall intrabony defects (5 x 5 x 5 mm) were created surgically on the distal and mesial sides of bilateral mandibular second and fourth premolars in four Beagle dogs. bFGF, enamel matrix derivative (EMD) and platelet-derived growth factor with beta-tricalcium phosphate (PDGF/beta-TCP) treatments, and sham-surgery (OFD) were rotated among the four defects in each animal, EMD and PDGF/beta-TCP serving as benchmark controls. The animals were euthanized for radiographic and histologic evaluation at 8 weeks. RESULTS: Bone formation was significantly greater in the bFGF group (4.11 +/- 0.77 mm) than in the EMD (3.32 +/- 0.71 mm; p<0.05) and OFD (3.09 +/- 0.52 mm; p<0.01) groups. The EMD (4.59 +/- 1.19 mm) and PDGF/beta-TCP (4.66 +/- 0.7 mm) groups exhibited significantly greater cementum regeneration with periodontal ligament-like tissue than the OFD group (2.96 +/- 0.69 mm; p<0.01). No significant differences were observed between the bFGF and the PDGF/beta-TCP groups in any of the histometric parameters. CONCLUSIONS: The candidate bFGF treatment supported periodontal regeneration comparable with that of established benchmarks: EMD and PDGF/beta-TCP.
Yoshinori Shirakata; Katsuyoshi Taniyama; Takehiko Yoshimoto; Motoharu Miyamoto; Naoshi Takeuchi; Takashi Matsuyama; Kazuyuki Noguchi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  37     ISSN:  1600-051X     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  374-81     Citation Subset:  D; IM    
Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
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MeSH Terms
Alveolar Bone Loss / drug therapy*
Bone Regeneration / drug effects*,  physiology
Bone Substitutes / therapeutic use
Dental Enamel Proteins / therapeutic use
Disease Models, Animal
Fibroblast Growth Factor 2 / physiology*,  therapeutic use
Mandible / drug effects*,  surgery
Periodontium / drug effects*,  physiology
Statistics, Nonparametric
Reg. No./Substance:
0/Bone Substitutes; 0/Dental Enamel Proteins; 0/enamel matrix proteins; 103107-01-3/Fibroblast Growth Factor 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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