Document Detail


Regenerative capacity of intravenous autologous, allogeneic and human mesenchymal stem cells in the infarcted pig myocardium-complicated by myocardial tumor formation.
MedLine Citation:
PMID:  18609048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Intravenous delivery of mesenchymal stem cells (MSCs) is an attractive approach for regeneration of infarcted myocardium. However, its efficacy is not well-defined in large animals. METHODS: Pigs (n =8) received intravenously autologous, allogeneic porcine or human MSCs (1 x 10(6) per kg bodyweight) labeled with fluorescent dye 48 hours post proximal LAD occlusion. Infarct size, histology and myocardial function were assessed 4 weeks later. RESULTS: Labeled MSCs migrated in the peri-infarct region resulting in improved myocardial function. Infarct size was larger in the control group (32+/-7%) compared to autologous (19+/-7%, p =0.008), allogeneic (24+/-4%, p =0.01) and human MSCs (26+/-5%, p =0.03). Fractional area shortening significantly increased after 4 weeks in pigs receiving autologous MSCs (34+/-7%, p =0.001), allogeneic MSCs (28+/-2%, p =0.004) and human MSCs (24+/-5%, p =0.027), but was lower in the control group (23+/-3%, n.s.). However, substantial callus formation and a non-malignant cardiac "tumor" containing mesenchymal tissue was observed in one animal treated with human MSCs. CONCLUSIONS: Intravenously administered MSCs prevent pathologic remodeling and scar formation but bare potential risks from inflammatory-related products.
Authors:
David Wolf; Adrian Reinhard; Anja Seckinger; Lisa Gross; Hugo A Katus; Alexander Hansen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  43     ISSN:  1651-2006     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-13     Completed Date:  2009-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  England    
Other Details:
Languages:  eng     Pagination:  39-45     Citation Subset:  IM    
Affiliation:
Department of Cardiology, University of Heidelberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Disease Models, Animal
Heart Neoplasms / etiology*,  pathology
Humans
Mesenchymal Stem Cell Transplantation / adverse effects*
Myocardial Contraction
Myocardial Infarction / pathology,  physiopathology,  surgery*
Myocardium / pathology*
Regeneration*
Swine
Time Factors
Transplantation, Autologous
Transplantation, Homologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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