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Regenerative Medicine for the Respiratory System: Distant Future or Tomorrow's Treatment?
MedLine Citation:
PMID:  23220914     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Regenerative medicine is a new field of biomedical science that focuses on the regeneration of tissues and organs and the restoration of organ function. Whereas regeneration of organ systems like bone, cartilage and heart has attracted intense scientific research over recent decades, regenerative medicine research regarding the respiratory system, including the trachea, the lung proper and the diaphragm, has lagged behind. However, the last five years have witnessed novel approaches and initial clinical applications of tissue-engineered constructs to restore organ structure and function. In this regard, the present paper briefly addresses the basics of regenerative medicine and introduces the key elements necessary for tissue regeneration, including (stem) cells, biomaterials and extracellular matrices. In addition, the current status of the (clinical) application of regenerative medicine to the respiratory system is discussed, and bottlenecks and recent approaches are identified. For the trachea, several initial clinical studies have been reported and have used various combinations of cells and scaffolds. Although promising, the methods used in these studies require optimization and standardization. For the lung proper, only (stem) cell-based approaches have been probed clinically, but it is becoming apparent that combinations of cells and scaffolds are required to successfully restore the lung's architecture and function. In the case of the diaphragm, clinical applications have focused on the use of decellularized scaffolds, but novel scaffolds, with or without cells, are clearly needed for true regeneration of diaphragmatic tissue. We conclude that respiratory treatment with regenerative medicine will not be realized tomorrow, but its future looks promising.
Authors:
Katrien M Brouwer; Henk R Hoogenkamp; Willeke F Daamen; Toin H van Kuppevelt
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-6
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  -     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Biochemistry, NCMLS, RUMC, Nijmegen, Netherlands.
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