| Regeneration of human infarcted heart muscle by intracoronary autologous bone marrow cell transplantation in chronic coronary artery disease: the IACT Study. | |
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MedLine Citation:
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PMID: 16256864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Stem cell therapy may be useful in chronic myocardial infarction (MI); this is conceivable, but not yet demonstrated in humans. BACKGROUND: After acute MI, bone marrow-derived cells improve cardiac function. METHODS: We treated 18 consecutive patients with chronic MI (5 months to 8.5 years old) by the intracoronary transplantation of autologous bone marrow mononuclear cells and compared them with a representative control group without cell therapy. RESULTS: After three months, in the transplantation group, infarct size was reduced by 30% and global left ventricular ejection fraction (+15%) and infarction wall movement velocity (+57%) increased significantly, whereas in the control group no significant changes were observed in infarct size, left ventricular ejection fraction, or wall movement velocity of infarcted area. Percutaneous transluminal coronary angioplasty alone had no effect on left ventricular function. After bone marrow cell transplantation, there was an improvement of maximum oxygen uptake (VO2max, +11%) and of regional 18F-fluor-desoxy-glucose uptake into infarct tissue (+15%). CONCLUSIONS: These results demonstrate that functional and metabolic regeneration of infarcted and chronically avital tissue can be realized in humans by bone marrow mononuclear cell transplantation. |
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Authors:
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Bodo E Strauer; Michael Brehm; Tobias Zeus; Thomas Bartsch; Christina Schannwell; Christine Antke; Rüdiger V Sorg; Gesine Kögler; Peter Wernet; Hans-Wilhelm Müller; Matthias Köstering |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 46 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-31 Completed Date: 2005-12-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1651-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich-Heine-University, Düsseldorf, Germany. strauer@med.uni-duesseldorf.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bone Marrow Transplantation* / methods Chronic Disease Coronary Artery Disease / surgery* Coronary Vessels Heart / physiology* Humans Male Middle Aged Myocardial Infarction / surgery* Myocardium* Regeneration |
| Comments/Corrections | |
Comment In:
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J Am Coll Cardiol. 2006 Jul 18;48(2):417; author reply 417-8
[PMID:
16843203
]
J Am Coll Cardiol. 2005 Nov 1;46(9):1659-61 [PMID: 16256865 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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