Document Detail


Regenerating new heart with stem cells.
MedLine Citation:
PMID:  23281411     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This article discusses current understanding of myocardial biology, emphasizing the regeneration potential of the adult human heart and the mechanisms involved. In the last decade, a novel conceptual view has emerged. The heart is no longer considered a postmitotic organ, but is viewed as a self-renewing organ characterized by a resident stem cell compartment responsible for tissue homeostasis and cardiac repair following injury. Additionally, HSCs possess the ability to transdifferentiate and acquire the cardiomyocyte, vascular endothelial, and smooth muscle cell lineages. Both cardiac and hematopoietic stem cells may be used therapeutically in an attempt to reverse the devastating consequences of chronic heart failure of ischemic and nonischemic origin.
Authors:
Piero Anversa; Jan Kajstura; Marcello Rota; Annarosa Leri
Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-02
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-03-11     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-70     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Adult Stem Cells*
Animals
Heart Failure / metabolism,  pathology,  therapy*
Hematopoietic Stem Cells*
Humans
Myocardial Ischemia / metabolism,  pathology,  therapy*
Myocardium / metabolism,  pathology
Regeneration*
Stem Cell Transplantation / methods*
Grant Support
ID/Acronym/Agency:
P01 AG043353/AG/NIA NIH HHS; P01 HL078825/HL/NHLBI NIH HHS; P01 HL092868/HL/NHLBI NIH HHS; R01 AG017042/AG/NIA NIH HHS; R01 AG026107/AG/NIA NIH HHS; R01 AG037490/AG/NIA NIH HHS; R01 AG037495/AG/NIA NIH HHS; R01 HL039902/HL/NHLBI NIH HHS; R01 HL065577/HL/NHLBI NIH HHS; R01 HL091021/HL/NHLBI NIH HHS; R01 HL105532/HL/NHLBI NIH HHS; R01 HL111183/HL/NHLBI NIH HHS; R01 HL114346/HL/NHLBI NIH HHS; R37 HL081737/HL/NHLBI NIH HHS
Comments/Corrections

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