Document Detail


Regadenoson, a selective A2A adenosine receptor agonist, causes dose-dependent increases in coronary blood flow velocity in humans.
MedLine Citation:
PMID:  17679059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Regadenoson is a selective A2A adenosine receptor agonist and vasodilator used to increase the heterogeneity of distribution of coronary blood flow during myocardial perfusion imaging. This study characterized the dose dependence of regadenoson-induced coronary hyperemia. METHODS AND RESULTS: An open-label, dose-escalation study of regadenoson (10-500 microg, rapid intravenous bolus) was performed in 34 subjects; in 4 additional subjects, the effect of aminophylline to reverse the response to regadenoson was determined. Intracoronary peak blood flow velocity in either the left anterior descending or left circumflex artery was measured by continuous Doppler signal recording, heart rate, central aortic blood pressure, and adverse effects were recorded. Regadenoson increased peak blood flow velocity by up to 3.4-fold in a dose-dependent manner. The mean duration of the increase in flow velocity of 2.5-fold or greater caused by 400 to 500 microg of regadenoson was 2.3 to 2.4 minutes. Regadenoson (400-500 microg) increased heart rate by up to 21 +/- 6 beats/min and decreased systolic blood pressure (-5 +/- 8 mm Hg to -24 +/- 16 mm Hg) and diastolic blood pressure (-8 +/- 4 mm Hg to -15 +/- 14 mm Hg). Aminophylline (100 mg) attenuated the increase in peak flow velocity but not tachycardia caused by 400 microg of regadenoson. CONCLUSION: The results of this study demonstrate the utility of regadenoson as a coronary vasodilator for myocardial perfusion imaging.
Authors:
Hsiao D Lieu; John C Shryock; Gregory O von Mering; Toufigh Gordi; Brent Blackburn; Ann W Olmsted; Luiz Belardinelli; Richard A Kerensky
Related Documents :
7578909 - The effects of distension of the stomach and the descending colon on phasic coronary bl...
14630989 - Coronary flow reserve in the newborn lamb: an intracoronary doppler guide wire study.
4045029 - Reduction in blood flow in normal and narrowed coronary arteries of dogs by leukotriene...
9093529 - Perfusion-induced changes in cardiac contractility and oxygen consumption are not endot...
2115539 - Large coronary arteries in humans are responsive to changing blood flow: an endothelium...
6690839 - Effect of descending thoracic aorta clamping and unclamping on phasic coronary blood flow.
8420229 - Blood viscosity during thrombolytic therapy with anistreplase in acute myocardial infar...
1861299 - Viability and functional characteristics of enterocystoplasty after ligation of the vas...
6708579 - Brain damage in profound hypothermia. perfusion versus circulatory arrest.
Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  14     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-08-06     Completed Date:  2007-08-30     Revised Date:  2010-04-12    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  514-20     Citation Subset:  IM    
Affiliation:
Portola Pharmaceuticals, South San Francisco, Calif, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aminophylline / pharmacology
Blood Flow Velocity / drug effects*
Coronary Circulation / drug effects*
Dose-Response Relationship, Drug
Female
Humans
Male
Middle Aged
Purines / pharmacology*
Pyrazoles / pharmacology*
Receptor, Adenosine A2A / agonists*
Tomography, Emission-Computed, Single-Photon / methods
Ultrasonography, Doppler
Vasodilator Agents / pharmacology
Chemical
Reg. No./Substance:
0/Purines; 0/Pyrazoles; 0/Receptor, Adenosine A2A; 0/Vasodilator Agents; 0/regadenoson; 317-34-0/Aminophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The role of quantitation in clinical nuclear cardiology: the University of Virginia approach.
Next Document:  Underestimation of extent of ischemia by gated SPECT myocardial perfusion imaging in patients with l...