Document Detail


Refractory thrombocytopenia in antiphospholipid syndrome.
MedLine Citation:
PMID:  15847038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thrombocytopenia is the second most common manifestation of antiphospholipid syndrome (APS). It is found in approximately 22% of the patients with this disease. Often it is not severe, platelet counts usually range between 50 x 10(9)/L and 150 x 10(9)/L without bleeding problems. Yet, it does not protect patients against thrombotic events. It rarely requires treatment and, due to similarities to idiopathic thrombocytopenic purpura (ITP), similar treatment rules usually apply. In this report two patients with APS are described who presented with severe thrombocytopenia that did not respond to standard treatment regimen namely glucocorticoids (GC) followed by intravenous immunoglobulin therapy (IVIG). Splenectomy had to be resorted to relieve the condition.
Authors:
B Sharma; S Kapoor; A N Malaviya
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of the Association of Physicians of India     Volume:  53     ISSN:  0004-5772     ISO Abbreviation:  J Assoc Physicians India     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-04-25     Completed Date:  2005-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505585     Medline TA:  J Assoc Physicians India     Country:  India    
Other Details:
Languages:  eng     Pagination:  147-9     Citation Subset:  IM    
Affiliation:
Jaipur Hospital, Lal Kothi, Jaipur.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antiphospholipid Syndrome / complications*,  diagnosis,  therapy
Female
Glucocorticoids / therapeutic use
Humans
Immunoglobulins / therapeutic use
Male
Middle Aged
Recurrence
Splenectomy
Thrombocytopenia / diagnosis,  etiology*,  therapy
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Immunoglobulins

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