| Refractory thrombocytopenia in antiphospholipid syndrome. | |
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MedLine Citation:
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PMID: 15847038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thrombocytopenia is the second most common manifestation of antiphospholipid syndrome (APS). It is found in approximately 22% of the patients with this disease. Often it is not severe, platelet counts usually range between 50 x 10(9)/L and 150 x 10(9)/L without bleeding problems. Yet, it does not protect patients against thrombotic events. It rarely requires treatment and, due to similarities to idiopathic thrombocytopenic purpura (ITP), similar treatment rules usually apply. In this report two patients with APS are described who presented with severe thrombocytopenia that did not respond to standard treatment regimen namely glucocorticoids (GC) followed by intravenous immunoglobulin therapy (IVIG). Splenectomy had to be resorted to relieve the condition. |
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Authors:
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B Sharma; S Kapoor; A N Malaviya |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of the Association of Physicians of India Volume: 53 ISSN: 0004-5772 ISO Abbreviation: J Assoc Physicians India Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-04-25 Completed Date: 2005-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505585 Medline TA: J Assoc Physicians India Country: India |
Other Details:
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Languages: eng Pagination: 147-9 Citation Subset: IM |
Affiliation:
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Jaipur Hospital, Lal Kothi, Jaipur. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antiphospholipid Syndrome / complications*, diagnosis, therapy Female Glucocorticoids / therapeutic use Humans Immunoglobulins / therapeutic use Male Middle Aged Recurrence Splenectomy Thrombocytopenia / diagnosis, etiology*, therapy |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Immunoglobulins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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