| Refractory status epilepticus due to acute hepatic porphyria in a pregnant woman: induced abortion as the sole therapeutic option? | |
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MedLine Citation:
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PMID: 15469454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 22-years old, 55 kg female patient in the twelfth week of pregnancy developed neuropsychiatric syndromes and in the following status epilepticus. Raised porphyrines and porphyrine precursors were found in the patient's urine. Despite intravenous glucose infusions and appropriate medication no reduction in seizure-frequency and neuropsychiatric syndromes was observed. An abortion was induced. After the interruption and starting of haem arginate therapy, seizure activity stopped and porphyrine precursors returned to normal levels, and after 6 weeks the patient was discharged in excellent clinical condition. This report describes a status epilepticus caused by acute hepatic porphyria, triggered by pregnancy, in a 22-years old woman. To our knowledge this is the first report of induced abortion as successful treatment in acute hepatic porphyria induced status epilepticus. |
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Authors:
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K Engelhardt; E Trinka; G Franz; I Unterberger; M Spiegel; R Beer; B Pfausler; A Kampfl; E Schmutzhard |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 11 ISSN: 1351-5101 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-10-07 Completed Date: 2004-12-20 Revised Date: 2006-09-05 |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 693-7 Citation Subset: IM |
Affiliation:
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Department of Neurology, University Hospital Innsbruck, Austria. klaus.engelhardt@uibk.ac.at |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Induced
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methods* Adult Arginine / therapeutic use Brain Mapping Diffusion Magnetic Resonance Imaging / methods Electroencephalography / methods Female Frontal Lobe / metabolism, pathology, physiopathology Heme / therapeutic use Humans Porphyrias, Hepatic / complications*, therapy Porphyrins / urine Pregnancy* Status Epilepticus / etiology*, therapy Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Porphyrins; 100438-92-4/heme arginate; 14875-96-8/Heme; 74-79-3/Arginine |
| Comments/Corrections | |
Comment In:
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Eur J Neurol. 2006 Jun;13(6):668-9
[PMID:
16796597
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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