Document Detail

Refractory linear IgA bullous dermatosis successfully treated with mycophenolate sodium.
MedLine Citation:
PMID:  19016105     Owner:  NLM     Status:  MEDLINE    
Linear IgA bullous dermatosis (LABD) is a rare, blistering autoimmune disease characterized by linear deposits of IgA at the basement membrane zone (BMZ), with the possible presence of circulating IgA anti-BMZ antibodies. LABD of childhood is usually self-healing, while in adults it follows a more prolonged course and refractory cases may rarely occur. The first-line treatment for LABD is dapsone in monotherapy or in combination with systemic corticosteroids, but various therapeutic approaches have been used in non-responder patients. We report two adult patients with refractory LABD successfully treated with enteric-coated mycophenolate sodium (EC-MPS), a recently introduced formulation of mycophenolic acid (MPA). MPA is an immunosuppressive agent that acts by inhibiting monophosphate dehydrogenase, a key enzyme in the novo synthesis of purines. Based on the present cases, we indicate EC-MPS as being a safe and effective adjuvant therapy in the treatment of LABD when dapsone or the other steroid-sparing drugs fail. It seems to offer an improved gastric side effect profile in comparison with the classic formulation of MPA, namely its ester mycophenolate mofetil (MMF).
Angelo V Marzano; Stefano Ramoni; Diana Spinelli; Elvio Alessi; Emilio Berti
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  19     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-18     Completed Date:  2009-02-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  England    
Other Details:
Languages:  eng     Pagination:  364-7     Citation Subset:  IM    
Institute of Dermatological Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.
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MeSH Terms
Dermatologic Agents / immunology,  therapeutic use*
Immunoglobulin A / drug effects*
Immunosuppressive Agents / immunology,  therapeutic use*
Mycophenolic Acid / analogs & derivatives*,  therapeutic use
Skin Diseases, Vesiculobullous / drug therapy*,  immunology
Treatment Outcome
Reg. No./Substance:
0/Dermatologic Agents; 0/Immunoglobulin A; 0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 9242ECW6R0/mycophenolate mofetil

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