Document Detail

Refractory gastrointestinal bleeding treated with thyroid hormone replacement.
MedLine Citation:
PMID:  11468443     Owner:  NLM     Status:  MEDLINE    
Although bleeding diathesis has been associated with hypothyroidism, refractory gastrointestinal bleeding has not been previously described in association with hypothyroidism. We report a patient who presented with refractory gastrointestinal bleeding over an 8-week period. Extensive work-up demonstrated small intestinal vascular malformations as the source of bleeding. Despite endoscopic therapy and hormonal therapy, bleeding continued and required transfusion of 54 units of packed red blood cells. Surgical therapy was offered to the patient but was declined. Ultimately, correction of the patient's underlying hypothyroidism resulted in cessation of gastrointestinal bleeding, and no further blood transfusion was necessary. To date, the patient has remained euthyroid without further gastrointestinal bleeding for 30 months.
K Fukunaga
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  33     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-24     Completed Date:  2001-10-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  145-7     Citation Subset:  IM    
Torrance Memorial Hospital, Department of Medicine, Torrance, California, USA.
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MeSH Terms
Aged, 80 and over
Arteriovenous Malformations / complications,  diagnosis
Gastrointestinal Hemorrhage / drug therapy*,  etiology
Hemorrhagic Disorders / drug therapy*,  etiology
Hypothyroidism / complications,  drug therapy*
Infusions, Intravenous
Intestine, Small / blood supply
Thyroid Function Tests
Thyroxine / administration & dosage*
Reg. No./Substance:

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