| Refractory Evans syndrome after autologous stem cell transplantation for multiple myeloma: management with a second transplantation. | |
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MedLine Citation:
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PMID: 20371959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of autoimmune disease after autologous stem cell transplantation (ASCT) is very rare in multiple myeloma (MM). We describe the first case of Evans syndrome after ASCT for MM. A 60-year-old man with MM received ASCT and subsequently developed Evans syndrome following two febrile episodes. The syndrome was refractory to conventional therapies but it was managed with a second ASCT. This unique complication was thought to have been triggered by an infection during the recovery of the immune system. We assumed that reconstructing the immune system via ASCT might eliminate infection-induced autoantibodies to platelets and erythrocytes. |
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Authors:
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Dai Chihara; Takashi Sakamoto; Kazue Arimoto-Miyamoto; Wataru Kishimoto; Tomoharu Takeoka; Masaaki Tsuji; Tatsuharu Ohno |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-04-01 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 49 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 683-7 Citation Subset: IM |
Affiliation:
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Division of Hematology and Immunology, Department of Internal Medicine, Ohtsu Red Cross Hospital, Ohtsu. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoimmune Diseases
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diagnosis,
etiology*,
surgery* Disease Management Fatal Outcome Hematopoietic Stem Cell Transplantation / adverse effects*, methods Humans Male Middle Aged Multiple Myeloma / pathology, surgery* Syndrome Transplantation Conditioning Transplantation, Autologous |
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