Document Detail


Refractory Urticarial Vasculitis as a Complication of Ulcerative Colitis Successfully Treated With Rituximab.
MedLine Citation:
PMID:  21778903     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Ulcerative colitis can be complicated by the development of leukocytoclastic vasculitis, a cutaneous vasculitis with the potential for systemic involvement. We present a man with a history of ulcerative colitis complicated by end-stage liver disease secondary to sclerosing cholangitis requiring a liver transplant. The patient developed new-onset vasculitis and diarrhea refractory to therapy with standard immunosuppression. He was treated with anti-CD20 therapy with a positive response. The basis of the vasculitis was likely one related to an underlying monoclonal paraprotein with cryoprecitable properties. Treatment with anti-B-cell therapy may be a new treatment option for patients with gammopathy-associated leukocytoclastic vasculitis.
Authors:
Arun Swaminath; Cynthia M Magro; Edward Dwyer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-20
Journal Detail:
Title:  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases     Volume:  -     ISSN:  1536-7355     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9518034     Medline TA:  J Clin Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the *Division of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center; †Dermatopathology, Weill Medical College of Cornell University; and ‡Division of Rheumatology, Department of Medicine, Columbia University Medical Center, New York, NY.
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