| Refractoriness of the immature rat epididymis to the early cadmium lesion. | |
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MedLine Citation:
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PMID: 7631433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ninety minutes after i.p. injection of 3 mumol of cadmium chloride/100 g body weight into immature, 15 day-old rats, the endothelial intercellular junctions of the caput epididymis capillaries showed none of the lesions such as loss of junctional associated ectoplasmic microfilaments, separation of interdigitated leaflets, disassembling of interendothelial tight junctions, passage of blood plasma and cells into the pericapillary space, platelet clumping and disintegration, and intracapillary clotting, which after the same dose are found in sexually mature rat epididymides. The resistance of the immature, physiologically intraabdominal epididymal capillary endothelium reminds one of the protection against cadmium that is brought about by surgical cryptorchidism in adult mature rats. We suggest that either local enzyme immaturity or the abdominal temperature (5 degrees C than scrotal temperature) may protect zinc enzymes against displacement by cadmium. |
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Authors:
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F L Sacerdote; J C Cavicchia |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ultrastructural pathology Volume: 19 ISSN: 0191-3123 ISO Abbreviation: Ultrastruct Pathol Publication Date: 1995 May-Jun |
Date Detail:
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Created Date: 1995-09-07 Completed Date: 1995-09-07 Revised Date: 2009-06-26 |
Medline Journal Info:
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Nlm Unique ID: 8002867 Medline TA: Ultrastruct Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 187-91 Citation Subset: IM |
Affiliation:
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Institute of Histology and Embryology, Faculty of Medical Science, National University of Cuyo, Mendoza, Argentina. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Body Temperature Cadmium / pharmacology* Cadmium Chloride Capillaries / drug effects, ultrastructure Chlorides / pharmacology* Endothelium, Vascular / drug effects, ultrastructure Epididymis / blood supply, drug effects*, ultrastructure* Male Microscopy, Electron Rats |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 10108-64-2/Cadmium Chloride; 7440-43-9/Cadmium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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