| Reflux profile of Chinese gastroesophageal reflux disease patients with combined multichannel intraluminal impedance-pH monitoring. | |
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MedLine Citation:
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PMID: 19638089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: To investigate the reflux profile of Chinese gastroesophageal reflux disease (GERD) patients with the aid of combined multichannel intraluminal impedance-pH (MII-pH) monitoring technique. METHODS: Consecutive patients presented with GERD symptoms were enrolled to erosive esophagitis (EE) group, non-erosive reflux disease (NERD) group and functional heartburn (FH) group after upper endoscopy, combined MII-pH monitoring and rabeprazole test. Another 20 healthy controls (HC) were recruited. RESULTS: Sixty-four GERD patients (EE:20, NERD:22, FH:22, HC:20) were enrolled. There were more episodes of liquid reflux and proximal reflux in EE and NERD groups than that in FH and HC groups (P < 0.05). Patients in FH and HC groups had higher proportion of mixed reflux (P = 0.000). The percentage of acid reflux in EE and NERD was much higher, while there was a higher percentage of weakly acidic reflux in FH and HC (P = 0.000). No significant difference was found in MII-pH parameters between groups with and without response to rabeprazole test except recumbent percentage time of esophageal pH value below 4 and episodes of proximal reflux. CONCLUSION: Erosive esophagitis and NERD patients had more liquid and proximal reflux episodes than FH patients and healthy controls. Acid and liquid reflux was predominant in the former two groups, while weakly acidic and mixed reflux was predominant in the latter two groups. |
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Authors:
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Ying L Xiao; Jin K Lin; Ting K Cheung; Nina Y H Wong; Ivan F N Hung; Benjamin C Y Wong; Sui Peng; An J Wang; Min H Chen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: 24 ISSN: 1440-1746 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-07-29 Completed Date: 2010-12-03 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: Australia |
Other Details:
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Languages: eng Pagination: 1113-8 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles
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therapeutic use Adult Aged Analysis of Variance Anti-Ulcer Agents / therapeutic use Case-Control Studies Chi-Square Distribution China / epidemiology Esophageal pH Monitoring / instrumentation* Esophagitis / drug therapy, epidemiology, physiopathology* Esophagoscopy Female Gastroesophageal Reflux / drug therapy, epidemiology, physiopathology* Humans Male Middle Aged Statistics, Nonparametric Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 32828355LL/rabeprazole |
| Comments/Corrections | |
Comment In:
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J Gastroenterol Hepatol. 2009 Oct;24(10):1581-2
[PMID:
19788597
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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