Document Detail

Reflux esophagitis in patients with Zollinger-Ellison syndrome.
MedLine Citation:
PMID:  1967239     Owner:  NLM     Status:  MEDLINE    
The incidence of ulcers of the stomach and duodenum and their response to medical therapy, in patients with Zollinger-Ellison syndrome is well described. However, reflux esophagitis is less well recognized. In this study we determined the frequency of reflux esophagitis in 122 patients with Zollinger-Ellison syndrome and examined their response to medical therapy. Esophageal symptoms, endoscopic abnormalities, or both were present in 61% of patients. Forty-five percent of patients had esophageal symptoms consisting of heartburn, dysphagia, or both. Forty-three percent of patients had endoscopic abnormalities of the esophagus, and 23% demonstrated moderate or severe disease. When sufficient antisecretory medication was administered to lower gastric acid secretion to less than 10 mEq/h in the last hour before the next dose of drug, 67% of the patients with reflux esophagitis responded with complete disappearance of symptoms and normalization of the endoscopic abnormalities. The other 33% of patients required an increase in medication to lower acid output to less than 5 mEq/h in 7% and less than 1 mEq/h in the other 26% to resolve symptoms and signs completely. We conclude that reflux esophagitis occurs in the majority of patients with Zollinger-Ellison syndrome and responds well to medical therapy, although one third of patients require intensive antisecretory medication.
L S Miller; R Vinayek; H Frucht; J D Gardner; R T Jensen; P N Maton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  98     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-02-20     Completed Date:  1990-02-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  341-6     Citation Subset:  AIM; IM    
Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
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MeSH Terms
Esophagitis, Peptic / drug therapy,  etiology*
Histamine H2 Antagonists / therapeutic use
Middle Aged
Omeprazole / therapeutic use
Parasympatholytics / therapeutic use
Zollinger-Ellison Syndrome / complications*
Reg. No./Substance:
0/Histamine H2 Antagonists; 0/Parasympatholytics; 73590-58-6/Omeprazole
Comment In:
Gastroenterology. 1990 Dec;99(6):1858   [PMID:  2227310 ]

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