| Reflex and steady state tears in patients with latent stromal herpetic keratitis. | |
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MedLine Citation:
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PMID: 11773017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare tear production in patients with stromal herpetic keratitis with that in healthy control subjects. METHODS: After instillation of 2 microL fluorescein into both eyes, the tear-fluorescein concentration was measured by fluorophotometry. During the first 10 minutes, steady state tear turnover (TTO-1) was determined. After a nasal alcohol stimulus to induce reflex tears, a second steady state tear turnover (TTO-2) was obtained during 15 minutes. The index of reflex lacrimation (IRL) was calculated as the percentage decrease in tear fluorescein concentration directly after the stimulus. TTO-1, TTO-2, and IRL were determined in the patients' affected eyes (n = 12), in the patients' healthy contralateral eyes, if possible (n = 9), and in one eye of healthy control subjects (n = 24). RESULTS: The TTO-1 in the affected and healthy eyes of patients was approximately two times lower than the TTO-1 in eyes of healthy control subjects (P = 0.012 and P = 0.024, respectively) and almost equal to the TTO-2 in eyes of healthy control subjects (P = 0.32 and P = 0.40). There were no significant differences in the values of TTO-1, IRL, and TTO-2 between affected and healthy eyes of patients (P > 0.5). IRL and TTO-2 did not differ significantly among the three groups (P > 0.5). CONCLUSIONS: Both eyes of the patients were dry. The dryness could be due to a defective reflex lacrimation under physiological conditions that can still be induced by nonphysiological nasal excitation. The cause of this may be demyelination of both trigeminal root entry zones as a result of a unilateral eye infection by the herpes virus. Another possibility is that dryness predisposes to herpetic infection or recurrent inflammation. |
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Authors:
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Sander Keijser; Jaap A van Best; Allegonda Van der Lelij; Martine J Jager |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 43 ISSN: 0146-0404 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-01-04 Completed Date: 2002-01-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 87-91 Citation Subset: IM |
Affiliation:
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Leiden University Medical Center, Department of Ophthalmology, Leiden, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blinking
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physiology* Corneal Stroma / virology Dry Eye Syndromes / metabolism Female Fluorescein / diagnostic use Fluorescent Dyes / diagnostic use Fluorophotometry Herpesvirus 1, Human / physiology Humans Keratitis, Herpetic / metabolism*, virology Lacrimal Apparatus / secretion* Male Middle Aged Tears / secretion* |
| Chemical | |
Reg. No./Substance:
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0/Fluorescent Dyes; 2321-07-5/Fluorescein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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