Document Detail


Reflex heart rate control in asthma. Evidence of parasympathetic overactivity.
MedLine Citation:
PMID:  3987376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The bronchial hyperreactivity characteristic of asthma may be related to enhanced parasympathetic nervous activity. We postulated that an abnormality in the autonomic control of airway caliber might be reflected by a parallel change in the reflex control of heart rate. We examined the heart-rate variations induced by deep breathing (respiratory sinus arrhythmia), the Valsalva maneuver, and standing up from the recumbent position in asthmatic subjects and nonasthmatic control subjects. The asthmatic patients had evidence of enhanced parasympathetic neural drive to the sinoatrial node, as manifested by a significantly greater magnitude of respiratory sinus arrhythmia, than the controls (p less than 0.0005). We were unable to induce a similar change in normal subjects by resistance breathing. A statistical analysis suggested the presence of a relationship between the magnitude of respiratory sinus arrhythmia and the degree of bronchial hyperreactivity in a group of asthmatic patients. Our results support the hypothesis that enhanced parasympathetic activity is an important factor in the pathogenesis of bronchial asthma.
Authors:
J M Kallenbach; T Webster; R Dowdeswell; S G Reinach; R N Millar; S Zwi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  87     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-06-17     Completed Date:  1985-06-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  644-8     Citation Subset:  AIM; IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adult
Airway Resistance
Arrhythmia, Sinus / physiopathology
Asthma / physiopathology*
Female
Functional Residual Capacity
Heart Rate*
Humans
Male
Parasympathetic Nervous System / physiopathology*
Peak Expiratory Flow Rate
Physical Exertion
Valsalva Maneuver

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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