| Reflex changes in breathing pattern evoked by inhalation of wood smoke in rats. | |
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MedLine Citation:
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PMID: 7928855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The acute ventilatory response to inhalation of wood smoke was studied in 58 anesthetized Sprague-Dawley rats. Wood smoke (approximately 6 ml) was inhaled spontaneously via a tracheal cannula. Within the first two breaths of smoke inhalation, either a slowing of respiration (SR) (n = 39) or an augmented inspiration (AI) (n = 19) was elicited consistently in each rat. The SR was primarily due to a prolongation of expiratory duration, whereas the AI was characterized by a two-step inspiratory flow leading to an exceedingly large tidal volume. Both initial responses, usually accompanied by bradycardia and hypotension, were reduced by inhaling smoke at a decreased concentration. After these initial responses, a delayed tachypnea developed and reached its peak 6-10 breaths after inhalation of smoke. Both the SR and AI were completely abolished by bilateral cervical vagotomy. In contrast, the delayed tachypneic response was not prevented by vagotomy but was significantly attenuated by denervation of peripheral chemoreceptors. We conclude that the initial responses to inhalation of several tidal breaths of wood smoke are mediated through vagal bronchopulmonary afferents, whereas the delayed tachypnea may involve nonvagal mechanisms that include a stimulation of peripheral chemoreceptors. |
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Authors:
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Y R Kou; C J Lai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 76 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1994-11-01 Completed Date: 1994-11-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2333-41 Citation Subset: IM |
Affiliation:
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Department of Physiology, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemoreceptor Cells / physiology Dose-Response Relationship, Drug Female Male Nerve Fibers / physiology Neurons, Afferent / physiology Rats Rats, Sprague-Dawley Reflex / physiology* Respiratory Mechanics / physiology* Smoke / adverse effects* Tidal Volume / physiology Vagotomy Wood* |
| Chemical | |
Reg. No./Substance:
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0/Smoke |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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