Document Detail

Reflex cardiovascular response to exercise is modulated by circulating vasopressin.
MedLine Citation:
PMID:  1359798     Owner:  NLM     Status:  MEDLINE    
Peripheral vasopressin (AVP) can act centrally to sensitize the arterial baroreflex and/or peripherally to attenuate regional blood flow by a direct vascular effect. Because plasma concentrations of AVP increase during exercise, this study examined the possibility that AVP is capable of modulating the reflex cardiovascular response to static muscle contraction. Thus, in anesthetized cats, the pressor [mean arterial pressure (MAP)], myocardial contractile (dP/dt), and heart rate responses to 30-45 s of electrically induced static contraction of the hindlimb muscles were compared before and after intravenous injection of the V1 receptor antagonist d[CH2)5Tyr(Me)]-AVP (V1-x, n = 7), V1-x plus the V2 receptor antagonist [d(CH2)5,D-Phe2,Ile4,Arg8,Ala9]vasopressin (V2-x, n = 5), or the ganglionic blocker hexamethonium chloride (n = 5). In three additional cats, the contraction-induced cardiovascular response was monitored before and after injection of V1-x + V2-x and after hexamethonium. Subsequent to treatment with V1-x, the MAP and dP/dt responses to contraction were augmented by 18 +/- 5 and 22 +/- 10%, respectively (P < 0.05). After injection of V1-x + V2-x, the MAP and dP/dt responses were augmented to a similar extent (32 +/- 6 and 40 +/- 17%, respectively; P < 0.05). However, there was no difference in the magnitude of augmentation of these responses between the two conditions. The heart rate response was not altered by either treatment. Ganglionic blockade eliminated the cardiovascular responses to contraction. Last, when the pressor and contractile responses to contraction were initially augmented by administration of V1-x + V2-x, subsequent ganglionic blockade abolished the entire cardiovascular response.(ABSTRACT TRUNCATED AT 250 WORDS)
C L Stebbins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  263     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-22     Completed Date:  1992-12-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1104-9     Citation Subset:  IM    
Department of Internal Medicine, University of California, Davis 95616.
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MeSH Terms
Arginine Vasopressin / blood*,  pharmacology
Blood Pressure / drug effects
Cardiovascular Physiological Phenomena*
Cardiovascular System / drug effects
Ganglionic Blockers / pharmacology
Hexamethonium Compounds / pharmacology
Injections, Intravenous
Myocardial Contraction / drug effects
Physical Exertion*
Receptors, Vasopressin / antagonists & inhibitors
Reflex / physiology*
Reg. No./Substance:
0/Ganglionic Blockers; 0/Hexamethonium Compounds; 0/Receptors, Vasopressin; 113-79-1/Arginine Vasopressin; 60-26-4/Hexamethonium

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