Document Detail

Reflex cardiac effects of local cutaneous cold exposure in dogs.
MedLine Citation:
PMID:  7396009     Owner:  NLM     Status:  MEDLINE    
Cardiovascular responses initiated by local cutaneous cooling were evaluated in 16 anesthetized dogs of which 8 were pretreated with propranolol. Heart rate, cardiac index (CI), and indices of ventricular contractility were significantly elevated in untreated animals during cold stimulation. Myocardial oxygen uptake (MVo2) and left ventricular work (LVW) were also increased, and cardiac mechanical efficiency was significantly reduced. Total peripheral vascular resistance remained unchanged. In the propranolol group, heart rate decreased by 12 beats/min, but CI was maintained constant during cold by a rise in stroke index. Left ventricular dP/dtmax was reduced and ventricular preload elevated, but LVW, MVo2, and cardiac efficiency were unchanged. These data indicate that local cutaneous cooling increases myocardial oxygen demand by reflexly elevating heart rate and cardiac contractility rather than by increasing cardiac afterload. The response is completely eliminated by beta-adrenergic blockade. The significance of these observations in regard to the cold-intolerant individual with coronary disease is discussed.
J F Borgia; S M Horvath
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  239     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-09-28     Completed Date:  1980-09-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H114-20     Citation Subset:  IM; S    
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MeSH Terms
Adaptation, Physiological
Cardiac Output
Cold Temperature*
Coronary Circulation
Heart / physiology*
Heart Rate
Myocardial Contraction
Myocardium / metabolism
Oxygen Consumption
Regional Blood Flow
Vasomotor System / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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