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Reflections on the theories of aging, of oxidative stress and of science in general. Is it time to abandon the free radical (oxidative stress) theory of aging?
MedLine Citation:
PMID:  24949668     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Significance: Aging and oxidative stress are complex phenomena and their understanding is of enormous theoretical and practical significance. Recent Advances: Numerous hypotheses and theories that attempt to explain these phenomena have been developed. These hypotheses and theories compete with each other, each claiming to be the correct one, while significantly contradicting each other. Critical issues: It is important to develop a maximally correct theory which then may trigger significant practical breakthroughs. Future directions: None of these theories is entirely correct or close enough to the truth. However, most of them contain many correct elements. Finding these correct elements is possible by analysis of these theories. Once the correct elements are found, they can be merged by synthesis in a better new theory. An analysis of some of the theories of aging followed by synthesis is attempted.
Authors:
Stefan I Liochev
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-20
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  -     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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