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Reflections on the mode of functioning of endocrine systems.
MedLine Citation:
PMID:  21199737     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The concept of hormones as chemical messengers that transmit information from one organ to other organs by way of circulating blood has implications that have not been made explicit. In this paper the concept is analyzed and is shown to be inconsistent with many observations. The previously proposed concepts of hormone multifunctionalities, hormonal multisignal messages, and the conversion of hormones into other hormones are shown to clarify conflicting observations as well as the congruous mode of functioning of endocrine systems with multifunctional hormones. A strategy is proposed for identifying the compositions and functions of the diverse multisignal messages conveyed by any hormone. The information so obtained could be useful for the development of more selective hormonal therapies.
Authors:
Juan José Mandoki; María Juana García-Mondragón; Beatriz Casa-Tirao; Fausto Alejandro Jiménez-Orozco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of medical research     Volume:  41     ISSN:  1873-5487     ISO Abbreviation:  Arch. Med. Res.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2011-01-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312706     Medline TA:  Arch Med Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  653-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 IMSS. Published by Elsevier Inc. All rights reserved.
Affiliation:
Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico, D.F., Mexico.
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