Document Detail

Reflection paper on the use of third and fourth generation cephalosporins in food producing animals in the European Union: development of resistance and impact on human and animal health.
MedLine Citation:
PMID:  20444006     Owner:  NLM     Status:  MEDLINE    
Resistance to third and fourth generation cephalosporins is rapidly increasing in bacteria infecting humans. Although many of these problems are linked to human to human transmission and to use of antimicrobials in human medicine, the potential role of community reservoirs such as food producing animals needs to be scrutinized. Resistance to third and fourth generation cephalosporins is emerging in enteric bacteria of food producing animals and also in food of animal origin. The genes encoding resistance to these cephalosporins are transferrable and often linked to other resistance genes. Systemic use of third and fourth cephalosporins selects for resistance, but co-selection by other antimicrobials is also likely to influence prevalence of resistance. Although there are many uncertainties, the potential consequences of a further increase of resistance to this critically important class of antimicrobials in bacteria colonising animals are serious. Measures to counter a further increase and spread of resistance among animals should therefore be considered.
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of veterinary pharmacology and therapeutics     Volume:  32     ISSN:  1365-2885     ISO Abbreviation:  J. Vet. Pharmacol. Ther.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-05-06     Completed Date:  2010-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910920     Medline TA:  J Vet Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  515-33     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / administration & dosage,  pharmacology*
Cephalosporins / administration & dosage,  pharmacology*
Drug Resistance, Multiple, Bacterial*
European Union
Food Contamination*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cephalosporins
C Greko / ; J I Badiola / ; B Catry / ; E van Duijkeren / ; M A Moreno / ; Matias Ferreira Pomba M C / ; S Pyörälä / ; M Ruzauskas / ; P Sanders / ; E J Threlfall / ; F Ungemach / ; K Törneke / ; J Torren-Edo / ; A Caprioli / ; D Mevius / ; J Wallman /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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