Document Detail


Reflection-mode multifocal optical-resolution photoacoustic microscopy.
MedLine Citation:
PMID:  23446704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Compared with single-focus optical-resolution photoacoustic microscopy (OR-PAM), multifocal OR-PAM utilizes both multifocal optical illumination and an ultrasonic array transducer, significantly increasing the imaging speed. A reflection-mode multifocal OR-PAM system based on a microlens array that provides multiple foci as well as an ultrasonic array transducer that receives the excited photoacoustic waves from all foci simultaneously is presented. Using a customized microprism to reflect the incident laser beam to the microlens array, the multiple optical foci are aligned confocally with the focal zone of the ultrasonic array transducer. Experiments show the reflection-mode multifocal OR-PAM is capable of imaging microvessels in vivo, and it can image a 6×5×2.5  mm³ volume at 16 μm lateral resolution in ∼2.5  min, which was limited by the signal multiplexing ratio and laser pulse repetition rate.
Authors:
Guo Li; Konstantin I Maslov; Lihong V Wang
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Publication Detail:
Type:  Letter; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  18     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-28     Completed Date:  2013-10-24     Revised Date:  2014-06-16    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  030501     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / blood supply
Ear / blood supply
Equipment Design
Mice
Mice, Nude
Microscopy, Acoustic / instrumentation*,  methods*
Microvessels / anatomy & histology,  chemistry
Photoacoustic Techniques / instrumentation,  methods*
Grant Support
ID/Acronym/Agency:
DP1 EB016986/DP/NCCDPHP CDC HHS; DP1 EB016986/EB/NIBIB NIH HHS; R01 CA134539/CA/NCI NIH HHS; R01 CA157277/CA/NCI NIH HHS; R01 CA159959/CA/NCI NIH HHS; R01 EB000712/EB/NIBIB NIH HHS; R01 EB008085/EB/NIBIB NIH HHS; U54 CA136398/CA/NCI NIH HHS
Comments/Corrections

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