Document Detail


Refining the threshold of toxicological concern (TTC) for risk prioritization of trace chemicals in food.
MedLine Citation:
PMID:  19531369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Due to ever-improving analytical capabilities, very low levels of unexpected chemicals can now be detected in foods. Although these may be toxicologically insignificant, such incidents often garner significant attention. The threshold of toxicological concern (TTC) methodology provides a scientifically defensible, transparent approach for putting low-level exposures in the context of potential risk, as a tool to facilitate prioritization of responses, including potential mitigation. The TTC method supports the establishment of tiered, health-protective exposure limits for chemicals lacking a full toxicity database, based on evaluation of the known toxicity of chemicals which share similar structural characteristics. The approach supports the view that prudent actions towards public health protection are based on evaluation of safety as opposed to detection chemistry. This paper builds on the existing TTC literature and recommends refinements that address two key areas. The first describes the inclusion of genotoxicity data as a way to refine the TTC limit for chemicals that have structural alerts for genotoxicity. The second area addresses duration of exposure. Whereas the existing TTC exposure limits assume a lifetime of exposure, human exposure to unintended chemicals in food is often only for a limited time. Recommendations are made to refine the approach for less-than-lifetime exposures.
Authors:
Susan Felter; Richard W Lane; Marie E Latulippe; G Craig Llewellyn; Stephen S Olin; Joseph A Scimeca; Thomas D Trautman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-14
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  47     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2236-45     Citation Subset:  IM    
Affiliation:
Procter and Gamble Company, Cincinnati, OH 45253, USA. felter.sp@pg.com
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MeSH Terms
Descriptor/Qualifier:
Dose-Response Relationship, Drug
Food Analysis / methods*
Food Contamination / prevention & control*
Food Supply / legislation & jurisprudence*
Humans
Legislation, Food*
Mutagens / chemistry,  toxicity
No-Observed-Adverse-Effect Level
Risk Assessment / methods*
Structure-Activity Relationship
Xenobiotics / analysis*,  toxicity
Chemical
Reg. No./Substance:
0/Mutagens; 0/Xenobiotics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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