Document Detail


Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions.
MedLine Citation:
PMID:  23211697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Personality traits are complex phenotypes related to psychosomatic health. Individually, various gene finding methods have not achieved much success in finding genetic variants associated with personality traits. We performed a meta-analysis of four genome-wide linkage scans (N=6149 subjects) of five basic personality traits assessed with the NEO Five-Factor Inventory. We compared the significant regions from the meta-analysis of linkage scans with the results of a meta-analysis of genome-wide association studies (GWAS) (N∼17 000). We found significant evidence of linkage of neuroticism to chromosome 3p14 (rs1490265, LOD=4.67) and to chromosome 19q13 (rs628604, LOD=3.55); of extraversion to 14q32 (ATGG002, LOD=3.3); and of agreeableness to 3p25 (rs709160, LOD=3.67) and to two adjacent regions on chromosome 15, including 15q13 (rs970408, LOD=4.07) and 15q14 (rs1055356, LOD=3.52) in the individual scans. In the meta-analysis, we found strong evidence of linkage of extraversion to 4q34, 9q34, 10q24 and 11q22, openness to 2p25, 3q26, 9p21, 11q24, 15q26 and 19q13 and agreeableness to 4q34 and 19p13. Significant evidence of association in the GWAS was detected between openness and rs677035 at 11q24 (P-value=2.6 × 10(-06), KCNJ1). The findings of our linkage meta-analysis and those of the GWAS suggest that 11q24 is a susceptible locus for openness, with KCNJ1 as the possible candidate gene.
Authors:
Najaf Amin; Jouke-Jan Hottenga; Narelle K Hansell; A Cecile J W Janssens; Marleen H M de Moor; Pamela A F Madden; Irina V Zorkoltseva; Brenda W Penninx; Antonio Terracciano; Manuela Uda; Toshiko Tanaka; Tonu Esko; Anu Realo; Luigi Ferrucci; Michelle Luciano; Gail Davies; Andres Metspalu; Goncalo R Abecasis; Ian J Deary; Katri Raikkonen; Laura J Bierut; Paul T Costa; Viatcheslav Saviouk; Gu Zhu; Anatoly V Kirichenko; Aaron Isaacs; Yurii S Aulchenko; Gonneke Willemsen; Andrew C Heath; Michele L Pergadia; Sarah E Medland; Tatiana I Axenovich; Eco de Geus; Grant W Montgomery; Margaret J Wright; Ben A Oostra; Nicholas G Martin; Dorret I Boomsma; Cornelia M van Duijn
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-05
Journal Detail:
Title:  European journal of human genetics : EJHG     Volume:  21     ISSN:  1476-5438     ISO Abbreviation:  Eur. J. Hum. Genet.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-18     Completed Date:  2013-10-29     Revised Date:  2014-08-05    
Medline Journal Info:
Nlm Unique ID:  9302235     Medline TA:  Eur J Hum Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  876-82     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chromosome Mapping / methods*
Chromosomes, Human, Pair 11 / genetics
Genome, Human / genetics*
Genome-Wide Association Study / methods*
Humans
Lod Score
Personality / genetics*
Personality Inventory
Phenotype
Polymorphism, Single Nucleotide
Potassium Channels, Inwardly Rectifying / genetics
Grant Support
ID/Acronym/Agency:
G0700704//Medical Research Council; K05 AA017688/AA/NIAAA NIH HHS; MH081802/MH/NIMH NIH HHS; R01 MH059160/MH/NIMH NIH HHS; Z99 AG999999/AG/NIA NIH HHS; ZIA AG000180-25/AG/NIA NIH HHS; ZIA AG000180-26/AG/NIA NIH HHS; ZIA AG000196-03/AG/NIA NIH HHS; ZIA AG000196-04/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/KCNJ1 protein, human; 0/Potassium Channels, Inwardly Rectifying
Comments/Corrections

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