Document Detail


Refinement of canine pancreatitis model: inducing pancreatitis by using endoscopic retrograde cholangiopancreatography.
MedLine Citation:
PMID:  19295057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The causes and treatments of pancreatitis have been studied in diverse species, but the canine pancreatitis model has been used most often due to its similarities to the condition in humans. Although pancreatitis in dogs can be induced readily by numerous methods, managing these dogs can be difficult because they often develop severe abdominal pain, vomiting, inappetance, and lethargy. In an effort to study pancreatitis, we performed a pilot study to determine whether an endoscopic pancreatic procedure would be possible in a dog and whether, through various manipulations, a new method of inducing pancreatitis could be developed. The model uses endoscopic retrograde cholangiopancreatography (ERCP), a common procedure in human gastroenterology that has been associated with postprocedural pancreatitis. Although all 8 dogs used in developing the ERCP model had both biochemical and histologic changes consistent with pancreatitis, 7 of the 8 dogs remained free of classic clinical signs of the disease. This method is presented as a refinement of a canine model and presents an alternative method of inducing pancreatitis, with decreased risk of developing associated clinical signs.
Authors:
Dawn S Ruben; Diana G Scorpio; K L Gabrielson; B W Simon; Jonathan M Buscaglia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Comparative medicine     Volume:  59     ISSN:  1532-0820     ISO Abbreviation:  Comp. Med.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-03-19     Completed Date:  2009-04-14     Revised Date:  2010-04-05    
Medline Journal Info:
Nlm Unique ID:  100900466     Medline TA:  Comp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  78-82     Citation Subset:  IM    
Affiliation:
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. druben1@jhmi.edu
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Amylases / blood
Animals
Cholangiopancreatography, Endoscopic Retrograde / adverse effects*,  methods*
Disease Models, Animal
Dogs
Fluoroscopy
Lipase / blood
Male
Pancreas / pathology*
Pancreatitis / blood,  etiology*,  pathology*
Pilot Projects
Postoperative Complications
Chemical
Reg. No./Substance:
EC 3.1.1.3/Lipase; EC 3.2.1.-/Amylases
Comments/Corrections
Erratum In:
Comp Med. 2009 Dec;59(6):516
Note: Gabrielson, K L [added]; Simon, B W [added]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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