Document Detail

Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies.
MedLine Citation:
PMID:  22039459     Owner:  NLM     Status:  MEDLINE    
Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non-telomeric rearrangements (N = 39), mainly observed in lymphoid proliferations and frequently associated with a highly complex karyotype. The 1p36 rearrangement was isolated in 12 cases, mainly myeloid disorders. The breakpoints on 1p36 were more widely distributed than previously reported, but with identifiable rare breakpoint cluster regions, such as the TP73 locus. We also found novel partner loci on 1p36 for the known multi-partner genes HMGA2 and RUNX1. We precised the common terminal 1p36 deletion, which has been suggested to have an adverse prognosis, in B-cell lymphomas [follicular lymphomas and diffuse large B-cell lymphomas with t(14;18)(q32;q21) as well as follicular lymphomas without t(14;18)]. Intrachromosomal telomeric repetitive sequences were detected in at least half the cases of telomeric rearrangements. It is unclear how the latter rearrangements occurred and whether they represent oncogenic events or result from chromosomal instability during oncogenesis.
Francois P Duhoux; Geneviève Ameye; Virginie Lambot; Christian Herens; Frédéric Lambert; Sophie Raynaud; Iwona Wlodarska; Lucienne Michaux; Catherine Roche-Lestienne; Elise Labis; Sylvie Taviaux; Elise Chapiro; Florence Nguyen-Khac; Florence Nguyen Khac; Stéphanie Struski; Sophie Dobbelstein; Nicole Dastugue; Eric Lippert; Frank Speleman; Nadine Van Roy; An De Weer; Katrina Rack; Pascaline Talmant; Steven Richebourg; Francine Mugneret; Isabelle Tigaud; Marie-Joëlle Mozziconacci; Sophy Laibe; Nathalie Nadal; Christine Terré; Jeanne-Marie Libouton; Anabelle Decottignies; Miikka Vikkula; Hélène A Poirel; ;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-10-21
Journal Detail:
Title:  PloS one     Volume:  6     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-31     Completed Date:  2012-02-28     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e26311     Citation Subset:  IM    
Center for Human Genetics, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
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MeSH Terms
Cell Line
Chromosome Aberrations*
Chromosomes, Human, Pair 1*
DNA-Binding Proteins / genetics*
Hematologic Neoplasms / genetics*
In Situ Hybridization, Fluorescence
Polymorphism, Single Nucleotide
Transcription Factors / genetics*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/PRDM16 protein, human; 0/Transcription Factors
Erratum In:
PLoS One. 2011 Dec 13;6(12). doi: 10.1371/annotation/3b5aaa87-72b6-49d3-9ec9-f4a656e12e3a
Note: Khac, Florence Nguyen [corrected to Nguyen-Khac, Florence]

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