Document Detail

Refined mapping of eight cosmid markers on human chromosome 22.
MedLine Citation:
PMID:  7916219     Owner:  NLM     Status:  MEDLINE    
Eight cosmid clones were regionally assigned to small subregions of chromosome 22 by hybridization with a total of 22 somatic cell hybrids. One cosmid was localized to the proximal part of 22q which contained the region commonly deleted in the DiGeorge syndrome. Seven cosmids showing restriction fragment length polymorphisms were localized to the telomeric region distal to the MB locus, which was reported to be frequently deleted in sporadic meningioma. These cosmids, when finely mapped and ordered, are considered useful for the identification of genetic alterations on this chromosome arm.
H Kurahashi; K Akagi; I Yana; T Melot; O Delattre; G Thomas; S Okada; S Takai; I Nishisho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Japanese journal of human genetics     Volume:  39     ISSN:  0916-8478     ISO Abbreviation:  Jpn. J. Hum. Genet.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-10-14     Completed Date:  1994-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9213239     Medline TA:  Jpn J Hum Genet     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  243-8     Citation Subset:  IM    
Department of Medical Genetics, Osaka University Medical School, Japan.
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MeSH Terms
Chromosome Mapping / methods
Chromosomes, Human, Pair 22*
Genetic Markers
Polymorphism, Restriction Fragment Length
Reg. No./Substance:
0/Genetic Markers

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