| Reference values of cord blood transferrin, ceruloplasmin, alpha-1 antitrypsin, prealbumin, and alpha-2 macroglobulin concentrations in healthy term newborns. | |
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MedLine Citation:
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PMID: 17479644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute phase proteins are sensitive markers of tissue necrosis and inflammatory process. These markers may be especially useful in the neonatal period, in which mortality and morbidity rates are high, because fetus and baby are subjected to numerous metabolic, genetic, physiologic and environmental injuries such as neonatal asphyxia and septicemia. The purpose of the present study was to establish normal cord blood levels of some acute phase proteins in healthy term neonates. Umbilical cord blood was obtained at the time of vaginal delivery in 60 newborn infants (30 girls, 30 boys). Specific protein concentrations were measured by nephelometric assay. Transferrin, ceruloplasmin, alpha-1 antitrypsin, prealbumin, and alpha-2 macroglobulin concentrations [arithmetic mean (+/- SD)] were found to be 199.7 (+/- 34.6) mg/dl, 14.6 (+/- 4.0) mg/dl, 160.2 (+/- 23.6) mg/dl, 11.9 (+/- 2.2) mg/dl, and 284.6 (+/- 44.4) mg/dl, respectively. Prealbumin levels for girls [12.9 (+/- 2.2)] were found to be significantly higher than those of boys [10.9 (+/- 1.8)] (p < 0.001), while there were no significant differences between the other proteins. We conclude that these results may be used as reference values for the diagnosis of pathological conditions in newborns. |
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Authors:
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Yüksel Aliyazicioğlu; Orhan Değer; Caner Karahan; Sermet Yildirmiş; Sükrü Küçüködük |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Turkish journal of pediatrics Volume: 49 ISSN: 0041-4301 ISO Abbreviation: Turk. J. Pediatr. Publication Date: 2007 Jan-Mar |
Date Detail:
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Created Date: 2007-05-07 Completed Date: 2007-05-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417505 Medline TA: Turk J Pediatr Country: Turkey |
Other Details:
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Languages: eng Pagination: 52-4 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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metabolism* Ceruloplasmin / metabolism Female Fetal Blood / metabolism* Humans Infant, Newborn Male Prealbumin / metabolism* Reference Values Transferrin / metabolism alpha 1-Antitrypsin / metabolism alpha-Macroglobulins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Prealbumin; 0/alpha 1-Antitrypsin; 0/alpha-Macroglobulins; 11096-37-0/Transferrin; EC 1.16.3.1/Ceruloplasmin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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