Document Detail


Reference values for clinical chemistry tests during normal pregnancy.
MedLine Citation:
PMID:  18485166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Reference values are usually defined based on blood samples from healthy men or nonpregnant women. This is not optimal as many biological markers changes during pregnancy and adequate reference values are of importance for correct clinical decisions. There are only few studies on the variations of laboratory tests during normal pregnancies, especially during the first two trimesters. It is thus a need to establish such reference values. DESIGN: Longitudinal study of laboratory markers in normal pregnancies. SETTING: Uppsala University Hospital, Sweden. POPULATION: Healthy pregnant females. METHODS: We have studied 25 frequently used laboratory tests during 52 normal pregnancies. Each woman was sampled up to nine times and the samples were divided according to collection time into the following groups: gestational week 7-17; week 17-24; week 24- 28; week 28-31; week 31-34; week 34-38; predelivery (0-2 weeks before delivery) and postpartum (> 6 weeks after delivery). The 2.5 and 97.5 percentiles for these markers were calculated according to the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference values. RESULTS: Reference intervals are reported for plasma alanine aminotransferase, albumin, alkaline phosphatase, pancreas amylase, apolipoprotein A1, apolipoprotein B, aspartate aminotransferase, bilirubin, calcium, chloride, creatinine, cystatin C, ferritin, gamma-glutamyltransferase, iron, lactate dehydrogenase, magnesium, phosphate, potassium, sodium, transferrin, triglycerides, thyroid-stimulating hormone, urate and urea during these pregnancy periods. CONCLUSIONS: Most of the analytes change during normal pregnancy. It is thus of importance to use special reference values during pregnancy.
Authors:
A Larsson; M Palm; L-O Hansson; O Axelsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  115     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-07-21     Revised Date:  2009-04-16    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  874-81     Citation Subset:  AIM; IM    
Affiliation:
Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden. anders.larsson@akademiska.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / analysis*
Clinical Chemistry Tests / standards
Female
Humans
Infant
Infant, Newborn
Pregnancy / physiology*
Pregnancy Trimesters
Prenatal Diagnosis / standards*
Reference Values
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections
Comment In:
BJOG. 2008 Dec;115(13):1716; author reply 1716-7   [PMID:  19035952 ]
BJOG. 2009 Apr;116(5):737   [PMID:  19298446 ]
BJOG. 2008 Nov;115(12):1580; author reply 1580-1   [PMID:  19035999 ]

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