Document Detail

Reference values for cardiopulmonary exercise testing in healthy volunteers: the SHIP study.
MedLine Citation:
PMID:  18768575     Owner:  NLM     Status:  MEDLINE    
Cardiopulmonary exercise testing (CPET) is a widely applied clinical procedure. The aim of the present study was to acquire a comprehensive set of reference values for cardiopulmonary responses to exercise and to evaluate possible associations with sex, age and body mass index (BMI). A standardised progressive incremental exercise protocol on a cycle ergometer was applied to 1,708 volunteers of a cross-sectional epidemiologic survey, called "Study of Health in Pomerania". Individuals with cardiopulmonary disorders, or echocardiographic or lung function pathologies, were excluded. The influence of potential confounding factors, such as smoking, taking beta-blockers, hypertension, diastolic dysfunction, BMI and physical activity, were analysed for their influencing power. Reference values of CPET parameters were determined by regression analyses. Of the volunteers, 542 current smokers and obese individuals were excluded for not being representative of a healthy population. The final sample size was 534 (253 males), with age 25-80 yrs. The current study provides a representative set of reference values for CPET parameters based on age and weight. Sex and age have a significant influence on exercise parameters. While addressing the problem of a selection bias, the current study provides the first comprehensive set of reference values obtained in a large number of healthy volunteers within a population-based survey.
B Koch; C Schäper; T Ittermann; T Spielhagen; M Dörr; H Völzke; C F Opitz; R Ewert; S Gläser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-03
Journal Detail:
Title:  The European respiratory journal     Volume:  33     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-05-08     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  389-97     Citation Subset:  IM    
Medical Faculty of the Ernst-Moritz-Arndt University, Dept of Pulmonary Medicine and Infectious Diseases, Friedrich-Loeffler-Str. 23, D-17475 Greifswald, Germany.
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MeSH Terms
Age Factors
Aged, 80 and over
Body Mass Index
Cardiovascular Diseases / diagnosis*,  metabolism*
Exercise Test / standards*
Middle Aged
Pulmonary Gas Exchange
Reference Values
Comment In:
Eur Respir J. 2009 Jul;34(1):286-7; author reply 287-8   [PMID:  19567615 ]

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