Document Detail

Reference values for amino acids in cerebrospinal fluid of children determined using ion-exchange chromatography with fluorimetric detection.
MedLine Citation:
PMID:  2766551     Owner:  NLM     Status:  MEDLINE    
One thousand specimens of CSF were collected from subjects ranging in age from newborn to 18 yr, who were undergoing a diagnostic lumbar puncture. Sixty-two samples were judged retrospectively as being suitable for calculating reference age-related values. The analyses were performed by an amino acid analyser using ion-exchange chromatography with fluorimetric detection giving a tenfold increase in sensitivity, thereby enhancing the diagnostic capabilities. As many as 36 known compounds could be detected, additionally 10 we could not identify. In children older than 3 yr nine of the identified compounds showed age-dependency. We found 22 amino acids to be significantly higher in infants younger than 1 yr, with only gamma-aminobutyric acid being significantly lower in infants. Alpha-aminoadipic acid showed a sex difference, being slightly higher in girls.
G P Gerrits; F J Trijbels; L A Monnens; F J Gabreëls; R A De Abreu; A G Theeuwes; B van Raay-Selten
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  182     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-09-27     Completed Date:  1989-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  271-80     Citation Subset:  IM    
Department of Pediatrics, University of Nijmegen, The Netherlands.
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MeSH Terms
Aging / cerebrospinal fluid
Amino Acids / cerebrospinal fluid*
Child, Preschool
Chromatography, Ion Exchange / methods
Infant, Newborn
Reference Standards
Sex Characteristics
Spectrometry, Fluorescence / methods
Reg. No./Substance:
0/Amino Acids

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